ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2024
Hepatic bile acid accretion correlates with cholestatic liver injury and therapeutic response in
Caroline Klindt, Jennifer K Truong, Ashley L Bennett, Kimberly J Pachura, Diran Herebian, Ertan Mayatepek, Tom Luedde, Matthias Ebert, Saul J Karpen, Paul A Dawson
Article in American journal of physiology. Gastrointestinal and liver physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Caroline KlindtDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States.
Jennifer K TruongDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States.
Ashley L BennettDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States.
Kimberly J PachuraDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States.
Diran HerebianDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany.
Ertan MayatepekDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany.
Tom LueddeDepartment of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine University, Duesseldorf, Germany.
Matthias EbertDepartment of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Saul J KarpenDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States.ORCID 0000-0002-3379-7592
Paul A DawsonDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States.ORCID 0000-0001-9760-4422
Funding
ILEAL BILE ACID TRANSPORTER METABOLISM AND REGULATIONR01DK047987 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAWSON, PAUL A · 2000 to 2021
$6.8M
MOLECULAR REGULATION OF HEPATIC TRANSPORTERSR01DK056239 · NIDDK · YALE UNIVERSITY · PI KARPEN, SAUL J. · 1999 to 2017
$4.8M
Modeling genetic contributions to biliary atresiaR01DK135815 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAUL J. KARPEN · 2023 to 2026
$2.4M
Hepatoprotective Mechanisms of Systemic Bile Acid Transporter InhibitorsR01DK140485 · NIDDK · EMORY UNIVERSITY · PI PAUL A DAWSON · 2024 to 2026
$1.9M
Deutsche Forschungsgemeinschaft (DFG) KL 3389/1-1HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK047987HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK056239HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK140485Mason Trust Fund at Emory UniversityMeredith Brown Fund at Emory UniversityNIDDK NIH HHS R01 DK047987NIDDK NIH HHS R01 DK056239NIDDK NIH HHS R01 DK135815NIDDK NIH HHS R01 DK140485
6 · The paper itself
Abstract
PubMed holds no abstract for this paper.
Indexed as
Bile Acids and SaltsLiverMice, KnockoutAnimalsCholestasisCytochrome P-450 Enzyme SystemDisease Models, AnimalFemaleHumansMaleMethylaminesMiceMice, Inbred C57BLReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearThiazepines3-((((3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl)methyl)amino)pentanedioic acidBile Acids and Saltscytochrome P-450 2C70, mouseCytochrome P-450 Enzyme SystemMethylaminesReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearThiazepinesbile acidschenodeoxycholic acidcholestasisfarnesoid X receptorileal bile acid transporter
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Hepatic bile acid accretion correlates with cholestatic liver injury and therapeutic response in · full record | OpenQuestion