Evidence map›Paper›PMID 39350230›Full record

ArticleBreast cancer research : BCR2024

Reproductive factors and mammographic density within the International Consortium of Mammographic Density: A cross-sectional study.

Jessica O'Driscoll, Anya Burton, Gertraud Maskarinec, Beatriz Perez-Gomez, Celine Vachon, Hui Miao, Martín Lajous, Ruy López-Ridaura, A Heather Eliassen, Ana Pereira and 44 more

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Article in Breast cancer research : BCR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Epidemiology, early detection, and management of breast cancer in China: A comprehensive review.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

54 authors.

Jessica O'DriscollSchool of Population Health, RCSI University of Medicine and Health Sciences, Beaux Lane House, Mercer Street Lower, Dublin 2, Ireland. jessicaodriscol20@rcsi.com.
Anya BurtonBristol Medical School, Translational Health Sciences, University of Bristol, Learning and Research Building, Level 2, Southmead Hospital, Bristol, UK.
Gertraud MaskarinecUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Beatriz Perez-GomezInstituto de Salud Carlos III, Madrid, Spain.
Celine VachonDepartment of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
Hui MiaoSaw Swee Hock School of Public Health, National University of Singapore, Singapore City, Singapore.
Martín LajousInstituto Nacional de Salud Pública, Cuernavaca, Mexico.
Ruy López-RidauraInstituto Nacional de Salud Pública, Cuernavaca, Mexico.
A Heather EliassenChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Ana PereiraInstituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile.
Maria Luisa GarmendiaInstituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile.
Rulla M TamimiPopulation Health Sciences, Weill Cornell Medicine, New York, NY, USA.
Kimberly BertrandSlone Epidemiology Center, Boston University, Boston, MA, USA.
Ava KwongDivision of Breast Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Giske UrsinCancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway.
Eunjung LeeDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Samera A QureshiUnit for Migration & Health, Norwegian Institute of Public Health, Oslo, Norway.
Huiyan MaDepartment of Computational and Quantitative Medicine, City of Hope National Medical Center, Duarte, CA, USA.
Sarah VinnicombeDivision of Cancer Research, Ninewells Hospital and Medical School, Dundee, UK.
Sue MossWolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.
Steve AllenDepartment of Diagnostic Radiology, Royal Marsden NHS Foundation Trust, London, UK.
Rose NdumiaAga Khan University Hospital, Nairobi, Kenya.
Sudhir VinayakAga Khan University Hospital, Nairobi, Kenya.
Soo-Hwang TeoBreast Cancer Research Group, University of Malaya Medical Centre, University of Malaya, Kuala Lumpur, Malaysia.
Shivaani MariapunCancer Research Malaysia, Subang Jaya, Malaysia.
Farhana FadzliBreast Cancer Research Unit, Faculty of Medicine, University of Malaya Cancer Research Institute, University of Malaya, Kuala Lumpur, Malaysia.
Beata PeplonskaDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland.
Chisato NagataDepartment of Epidemiology & Preventive Medicine, Graduate School of Medicine, Gifu University, Gifu, Japan.
Jennifer StoneGenetic Epidemiology Group, School of Population and Global Health, University of Western Australia, Perth, WA, Australia.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
Graham GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
Vahit OzmenFaculty of Medicine, Istanbul University, Istanbul, Turkey.
Mustafa Erkin AribalDepartment of Radiology, School of Medicine, Acibadem University, Istanbul, Turkey.
Joachim SchüzEnvironment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, Lyon, France.
Carla H Van GilsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Johanna O P WandersJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Reza SirousDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Mehri SirousRadiology Department, Isfahan University of Medical Sciences, Isfahan, Iran.
John HipwellCentre for Medical Image Computing, University College London, London, UK.
Jisun KimAsan Medical Center, Seoul, Republic of Korea.
Jong Won LeeAsan Medical Center, Seoul, Republic of Korea.
Mikael HartmanSaw Swee Hock School of Public Health, National University of Singapore, Singapore City, Singapore.
Jingmei LiDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.
Christopher ScottDepartment of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
Anna M ChiarelliOntario Breast Screening Program, Cancer Care Ontario, Toronto, ON, Canada.
Linda LintonPrincess Margaret Cancer Centre, Toronto, ON, Canada.
Marina PollanInstituto de Salud Carlos III, Madrid, Spain.
Anath Arzee FlugelmanThe Rapport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Dorria SalemWoman Imaging Unit, Radiodiagnosis Department, Kasr El Aini, Cairo University Hospitals, Cairo, Egypt.
Rasha KamalWoman Imaging Unit, Radiodiagnosis Department, Kasr El Aini, Cairo University Hospitals, Cairo, Egypt.
Norman BoydPrincess Margaret Cancer Centre, Toronto, ON, Canada.
Isabel Dos-Santos-SilvaWoman Imaging Unit, Radiodiagnosis Department, Kasr El Aini, Cairo University Hospitals, Cairo, Egypt.
Valerie McCormackEnvironment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, Lyon, France.
Maeve MulloolySchool of Population Health, RCSI University of Medicine and Health Sciences, Beaux Lane House, Mercer Street Lower, Dublin 2, Ireland.

Funding

International Pooling Project of Mammographic DensityR03CA167771 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI MCCORMACK, VALERIE · 2012 to 2013
$105k
Health Research Board EIA-2019-012NCI NIH HHS R03 CA167771World Health Organization 001
6 · The paper itself

Abstract

backgroundElevated mammographic density (MD) for a woman's age and body mass index (BMI) is an established breast cancer risk factor. The relationship of parity, age at first birth, and breastfeeding with MD is less clear. We examined the associations of these factors with MD within the International Consortium of Mammographic Density (ICMD).

methodsICMD is a consortium of 27 studies with pooled individual-level epidemiological and MD data from 11,755 women without breast cancer aged 35-85 years from 22 countries, capturing 40 country-& ethnicity-specific population groups. MD was measured using the area-based tool Cumulus. Meta-analyses across population groups and pooled analyses were used to examine linear regression associations of square-root (√) transformed MD measures (percent MD (PMD), dense area (DA), and non-dense area (NDA)) with parity, age at first birth, ever/never breastfed and lifetime breastfeeding duration. Models were adjusted for age at mammogram, age at menarche, BMI, menopausal status, use of hormone replacement therapy, calibration method, mammogram view and reader, and parity and age at first birth when not the association of interest.

resultsAmong 10,988 women included in these analyses, 90.1% (n = 9,895) were parous, of whom 13% (n = 1,286) had ≥ five births. The mean age at first birth was 24.3 years (Standard deviation = 5.1). Increasing parity (per birth) was inversely associated with √PMD (β: - 0.05, 95% confidence interval (CI): - 0.07, - 0.03) and √DA (β: - 0.08, 95% CI: - 0.12, - 0.05) with this trend evident until at least nine births. Women who were older at first birth (per five-year increase) had higher √PMD (β:0.06, 95% CI:0.03, 0.10) and √DA (β:0.06, 95% CI:0.02, 0.10), and lower √NDA (β: - 0.06, 95% CI: - 0.11, - 0.01). In stratified analyses, this association was only evident in women who were post-menopausal at MD assessment. Among parous women, no associations were found between ever/never breastfed or lifetime breastfeeding duration (per six-month increase) and √MD.

conclusionsAssociations with higher parity and older age at first birth with √MD were consistent with the direction of their respective associations with breast cancer risk. Further research is needed to understand reproductive factor-related differences in the composition of breast tissue and their associations with breast cancer risk.

Indexed as

Breast DensityBreast NeoplasmsMammographyReproductive HistoryAdultAgedAged, 80 and overBody Mass IndexBreast FeedingCross-Sectional StudiesFemaleHumansMammary Glands, HumanMiddle AgedParityPregnancyAge at first birthBreastfeedingMammographic densityParityReproductive factors

Identifiers

PMID39350230
PMCPMC11443712

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.