ArticleBMC endocrine disorders2024
Associations of metabolic syndrome and its components with sarcopenia, and the mediating role of insulin resistance: Findings from NHANES database.
Article in BMC endocrine disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- Association between metabolic dysregulation and frailty in four prospective cohorts.Journal of health, population, and nutrition · 2026Article
- Global prevalence of metabolic syndrome among individuals with sarcopenia: a systematic review and meta-analysis of 72,129 patients.Diabetology & metabolic syndrome · 2026Review
- Article
- Association between triglyceride-glucose index and sarcopenia in older adults without either dysglycemia or central obesity: a cross-sectional study from CHARLS.Open medicine (Warsaw, Poland) · 2026Article
- The Relationship between Sarcopenia and All-Cause and Cardiovascular Mortality Risk among Middle-Aged and Older Adults across Stages 0-3 of Cardiovascular-Kidney-Metabolic Syndrome: Evidence from NHANES and CHARLS.Cardiorenal medicine · 2026Article
- Association Between Fasting Insulin Levels and Handgrip Strength: A Cross-Sectional Study Using the Korean National Health and Nutrition Examination Survey.Journal of clinical medicine · 2025Article
- Association of triglyceride-glucose index and atherogenic index of plasma with sarcopenia across different glucose metabolism states: the mediating role of oxidative stress and chronic inflammation.European journal of medical research · 2025Article
- Skeletal muscle and MASLD: Mechanistic and clinical insights.Hepatology communications · 2025Review
- Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration.Cardiovascular diabetology · 2025Article
- Association of Dietary Antioxidant Potential with Sarcopenia in Hypertension.Reviews in cardiovascular medicine · 2025Article
- Association of triglyceride-glucose index and its combinations with sarcopenia among community-dwelling older adults: based on the Chongqing Aging and Sarcopenia Evaluation (CHASE) cohort.Frontiers in physiology · 2025Article
- Nonlinear association between depressive symptoms and homeostasis model assessment of insulin resistance: a cross-sectional analysis in the American population.Frontiers in psychiatry · 2025Article
- Construct prediction models for low muscle mass with metabolic syndrome using machine learning.PloS one · 2025Article
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4 authors.
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Abstract
backgroundTo investigate the association between metabolic syndrome (MetS) and its components with sarcopenia, and to explore the extent to which insulin resistance (IR) mediates this association, using data from the National Health and Nutrition Examination Survey (NHANES).
methodsWe analyzed cross-sectional data from 15,779 adults in the NHANES from 1999 to 2006 and 2011-2018. Multivariable logistic regression models were used to determine the odds ratios (ORs) between MetS, its components, the number of MetS components, and sarcopenia. Mediation analysis was performed to explore the role of the homeostatic model assessment of insulin resistance (HOMA-IR) in MetS and its components-induced sarcopenia.
resultIn the fully adjusted model, MetS increased the prevalence of sarcopenia by 1.96-fold (95% CI: 1.73-2.22). Among the individual components, central obesity, hypertension, and hyperglycemia were associated with an increased prevalence of sarcopenia. Sarcopenia prevalence also increased linearly with the number of MetS components, with the highest prevalence observed in the presence of all five components (OR: 3.80, 95% CI: 2.79-5.16). Sex-stratified analysis showed that the prevalence of MetS for sarcopenia was higher in males than females. The mediating effects of HOMA-IR on the association between MetS and its components (central obesity, hypertension, and hyperglycemia) with sarcopenia were significant, with mediation effects of 51.7%, 30.7%, 33.2%, and 79.1%, respectively. There was no significant direct association between hyperglycemia and sarcopenia beyond the HOMA-IR pathway.
conclusionMetS and its individual components, excluding hypertriglyceridemia and low high density lipoprotein cholesterol, were associated with a higher prevalence of sarcopenia, especially in males. This association was partially or fully mediated by IR.
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