Evidence map›Paper›PMID 39349760›Full record

ReviewNature reviews. Genetics2025

Inference and applications of ancestral recombination graphs.

Rasmus Nielsen, Andrew H Vaughn, Yun Deng

Abstract readReview
In one paragraph

Review in Nature reviews. Genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Review
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  17. Review
  18. Polarising SNPs Without Outgroup.Molecular ecology resources · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rasmus NielsenDepartment of Integrative Biology and Department of Statistics, UC Berkeley, Berkeley, CA, USA. rasmus_nielsen@berkeley.edu.ORCID http://orcid.org/0000-0003-0513-6591
Andrew H Vaughn *Center for Computational Biology, UC Berkeley, Berkeley, CA, USA.
Yun Deng *Center for Computational Biology, UC Berkeley, Berkeley, CA, USA.

Funding

Scalable Computational Methods for Genealogical Inference: from species level to single cellsR01HG013117 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Ian H Holmes, RASMUS NIELSEN · 2024 to 2026
$1.7M
Enabling Precision Genomics Using Adaptive VariationR01GM138634 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI NIELSEN, RASMUS · 2020 to 2023
$1.7M
Inference and application of graphs for genomic dataR35GM153400 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI RASMUS NIELSEN · 2024 to 2026
$1.3M
Scalable Computational Methods for Genealogical Inference: from species level to single cellsR56HG013117 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HOLMES, IAN H, NIELSEN, RASMUS · 2023 to 2023
$315k
NHGRI NIH HHS R01 HG013117NHGRI NIH HHS R56 HG013117NIGMS NIH HHS R01 GM138634NIGMS NIH HHS R35 GM153400
6 · The paper itself

Abstract

Ancestral recombination graphs (ARGs) summarize the complex genealogical relationships between individuals represented in a sample of DNA sequences. Their use is currently revolutionizing the field of population genetics and is leading to the development of powerful new methods to elucidate individual and population genetic processes, including population size history, migration, admixture, recombination, mutation and selection. In this Review, we introduce the readers to the structure of ARGs and discuss how they relate to processes such as recombination and genetic drift. We explore differences and similarities between methods of estimating ARGs and provide concrete illustrative examples of how ARGs can be used to elucidate population-level processes.

Indexed as

Genetics, PopulationModels, GeneticRecombination, GeneticAnimalsEvolution, MolecularGenetic DriftHumansPedigree

Identifiers

PMID39349760
PMCPMC12036574

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.