Evidence map›Paper›PMID 39349682›Full record

SynthesisCommunications biology2024

Genome-wide association studies for pelvic organ prolapse in the Japanese population.

Masatoshi Matsunami, Minako Imamura, Asuka Ashikari, Xiaoxi Liu, Kohei Tomizuka, Keiko Hikino, Kosei Miwa, Katsumi Kadekawa, Tetsuji Suda, Biobank Japan project and 4 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Unraveling the Causal Linkages ofBioMed research international · 2026
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Masatoshi Matsunami *Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.ORCID 0000-0003-4109-2493
Minako Imamura *Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.ORCID 0000-0002-1147-7627
Asuka AshikariDepartment of Urology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Xiaoxi LiuLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0002-1933-8613
Kohei TomizukaLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Keiko HikinoLaboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0002-4852-2401
Kosei MiwaUrogyne Center, Japanese Red Cross Gifu Hospital, Gifu, Japan.
Katsumi KadekawaDepartment of Urology, Okinawa Kyodo Hospital, Okinawa, Japan.
Tetsuji SudaDepartment of Urology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Biobank Japan project
Koichi MatsudaInstitute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-7292-2686
Minoru MiyazatoDepartment of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Chikashi TeraoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. chikashi.terao@riken.jp.ORCID 0000-0002-6452-4095
Shiro MaedaDepartment of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan. smaeda@med.u-ryukyu.ac.jp.ORCID 0000-0001-6688-9875

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pelvic organ prolapse (POP) affects approximately 40% of elderly women, characterized by the descent of the pelvic organs into the vaginal cavity. Here we present the results of a genome-wide association study (GWAS) for susceptibility to POP comprising 771 cases and 76,625 controls in the Japanese population. We identified a significant association of WT1 locus with POP in the Japanese population; rs10742277; odds ratio (OR) = 1.48, 95% confidence interval (CI), 1.29-1.68, P = 6.72 × 10

Indexed as

Genetic Predisposition to DiseasePelvic Organ ProlapseAgedCase-Control StudiesEast Asian PeopleFemaleGenome-Wide Association StudyHumansJapanJapanese peopleMiddle AgedPolymorphism, Single NucleotideReceptor, Fibroblast Growth Factor, Type 2FGFR2 protein, humanReceptor, Fibroblast Growth Factor, Type 2

Identifiers

PMID39349682
PMCPMC11443051

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.