ArticleNature neuroscience2024
Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain.
Abstract read
In one paragraph
Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- CXCL13⁺ CD4⁺ T cells are associated with B-cell recruitment and lesion progression in cerebral cavernous malformations.Journal of neuroinflammation · 2026Article
- Beyond the barrier: Targeting blood-brain interactions for neuroprotection and repair.Neural regeneration research · 2026Article
- One-pot fabrication of high-strength Janus hydrogel for wet tissue hemostasis and intestinal/intrauterine anti-adhesion.Nature communications · 2026Article
- Diffuse neuroinflammation and immature neuron loss in fetal Rhesus macaques after short-term intrauterine infection.Journal of neuroinflammation · 2026Article
- Article
- Developmental stage-dependent transcriptomic responses to neonatal intraventricular hemorrhage.Journal of neuroinflammation · 2025Article
- Engineering NO delivery system renormalizes the excitability of inhibitory interneurons after spinal cord injuryBioactive materials · 2025Article
- epDevAtlas: mapping GABAergic cells and microglia in the early postnatal mouse brain.Nature communications · 2025Article
- Article
- A Metal-Peptide Framework as a Nanozyme for the Attenuation of Amyloid‑β Aggregation and Reactive Oxygen Species.JACS Au · 2025Article
- Identification and validation of a novel lymph node metastasis-related model for papillary thyroid carcinoma to predict the prognosis.Gland surgery · 2025Article
- Pathogenesis of Germinal Matrix Hemorrhage: Insights from Single-Cell Transcriptomics.Annual review of pathology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors.
Jiapei ChenDepartment of Pathology and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Elizabeth E CrouchBiomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4110-9892
Miriam E ZawadzkiDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Kyle A JacobsDepartment of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4411-7855
Lakyn N MayoDepartment of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6642-2332
Jennifer Ja-Yoon ChoiDepartment of Pathology and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0009-0009-8189-4694
Pin-Yeh LinDepartment of Pathology and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Saba ShaikhUCSF CoLab, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0009-0000-9272-3713
Jessica TsuiUCSF CoLab, University of California San Francisco, San Francisco, CA, USA.
Susana Gonzalez-GraneroLaboratory of Comparative Neurobiology, Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia and CIBERNED-ISCIII, Valencia, Spain.
Shamari WallerDepartment of Pathology and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Avani KelekarDepartment of Pathology and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Gugene KangDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Edward J ValenzuelaDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Janeth Ochoa BirruetaDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Loukas N DiafosDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Kaylee Wedderburn-PughBiomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.
Barbara Di MarcoDepartment of Clinical Neurobiology, University Hospital Heidelberg and German Cancer Research Center, Heidelberg, Germany.
Wenlong XiaDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Claudia Z HanDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Nicole G CoufalDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Christopher K GlassDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Stephen P J FancyBiomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2818-8258
Julieta AlfonsoDepartment of Clinical Neurobiology, University Hospital Heidelberg and German Cancer Research Center, Heidelberg, Germany.
Arnold R KriegsteinBiomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5742-2990
Michael C OldhamBiomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7633-6932
Jose Manuel Garcia-VerdugoLaboratory of Comparative Neurobiology, Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia and CIBERNED-ISCIII, Valencia, Spain.ORCID http://orcid.org/0000-0001-9872-6499
Matthew L KutysBiomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-0752-649X
Maria K LehtinenDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7243-2967
Alexis J CombesDepartment of Pathology and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Eric J HuangDepartment of Pathology and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. eric.huang2@ucsf.edu.ORCID http://orcid.org/0000-0002-5381-3801
Funding
Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1MMedical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7MRegulation of Cellular Pathwaysin Human Brain DevelopmentP01NS083513 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PIAO, XIANHUA · 2014 to 2024
$12.6MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4MA Functional and Selective Toolkit for Choroid Plexus NetworksRF1DA048790 · NIDA · BOSTON CHILDREN'S HOSPITAL · PI LEHTINEN, MARIA, MOORE, CHRISTOPHER I · 2019 to 2019
$3.3MTargeting the Choroid Plexus-Cerebrospinal Fluid System to Treat Post-Hemorrhagic HydrocephalusR01NS129823 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI MARIA LEHTINEN · 2023 to 2026
$2.6MNeuroinflammation and vascular development in GMHR01NS132595 · NINDS · WASHINGTON UNIVERSITY · PI Eric J Huang · 2023 to 2026
$2.2MDevelopmental Topology of the Human Cerebral CortexR35NS137344 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARNOLD KRIEGSTEIN · 2025 to 2026
$2.1MThe Contribution of Microglial MEF2C to Brain DevelopmentR01NS124637 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Nicole Gabriele Coufal · 2022 to 2026
$2.0MMechanisms of oligodendroglial ciliary function in white matter injury repairR01NS128021 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Stephen Philip James Fancy · 2023 to 2026
$1.6MDecoding cortical Notch signaling and morphogenic instruction at cell-cell interfacesR35GM150987 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KUTYS, MATTHEW L · 2023 to 2025
$1.3MMural stem cells in normal development and germinal matrix hemorrhage in the preterm human brainK08NS116161 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CROUCH, ELIZABETH ERIN · 2021 to 2025
$1.1MAmerican Heart Association (American Heart Association, Inc.) Grant #23IPA1051611/2023BLRD VA I01 BX001108NIA NIH HHS R21 AG072232NICHD NIH HHS K12 HD000850NICHD NIH HHS P50 HD105351NIDA NIH HHS RF1 DA048790NIGMS NIH HHS R35 GM150987NIGMS NIH HHS T32 GM144273NIH HHS S10 OD028611NIMH NIH HHS K99 MH129983NIMH NIH HHS R00 MH129983NINDS NIH HHS K08 NS116161NINDS NIH HHS P01 NS083513NINDS NIH HHS R01 NS124637NINDS NIH HHS R01 NS128021NINDS NIH HHS R01 NS129823NINDS NIH HHS R01 NS132595NINDS NIH HHS R21 NS133891NINDS NIH HHS R35 NS137344
Abstract
Germinal matrix hemorrhage (GMH) is a devastating neurodevelopmental condition affecting preterm infants, but why blood vessels in this brain region are vulnerable to rupture remains unknown. Here we show that microglia in prenatal mouse and human brain interact with nascent vasculature in an age-dependent manner and that ablation of these cells in mice reduces angiogenesis in the ganglionic eminences, which correspond to the human germinal matrix. Consistent with these findings, single-cell transcriptomics and flow cytometry show that distinct subsets of CD45
Indexed as
BrainAngiogenesisAnimalsCerebral HemorrhageFemaleHumansInfant, NewbornInfant, PrematureMaleMiceMice, Inbred C57BLMicrogliaNeovascularization, Pathologic
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.