ArticleNPJ systems biology and applications2024
Spatial interactions modulate tumor growth and immune infiltration.
Article in NPJ systems biology and applications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Natural Killer Cell Immunotherapy in Solid Tumors: Microenvironmental Obstacles and Translational 3D Models.Biology · 2026Review
- Data-intensive immune network modelling for One Health.Briefings in bioinformatics · 2026Review
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- Mechanistic learning to predict and understand minimal residual disease.bioRxiv : the preprint server for biology · 2026Article
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- Review
- Modelling Immune Dynamics in Locally Advanced MSI-H/dMMR Colorectal Cancer with Neoadjuvant Pembrolizumab Treatment: From Differential Equations to an Agent-Based Framework.Bulletin of mathematical biology · 2026Article
- Exercise-derived extracellular vesicles in oncology: a new frontier for translational nanomedicine.Journal of translational medicine · 2026Review
- Astrocyte Reprogramming Drives Tumor Progression and Chemotherapy Resistance in Agent-Based Models of Breast Cancer Brain Metastases.Bulletin of mathematical biology · 2025Article
- Optimization of Immune Checkpoint Blockade via a Multiscale Model System.Computational and systems oncology · 2025Article
- Article
- Challenges and opportunities for the next generation of computational tumor models.PLoS biology · 2025Article
- Reciprocal Modulation of Tumour and Immune Cell Motility: Uncovering Dynamic Interplays and Therapeutic Approaches.Cancers · 2025Review
- Metastability in the mixing/demixing of two species with reciprocally concentration-dependent diffusivity.Frontiers in network physiology · 2025Article
- ESCRT may function as a tumor biomarker, transitioning from pan-cancer analysis to validation within breast cancer.Frontiers in immunology · 2025Article
- The role of various collagen types in tumor biology: a review.Frontiers in oncology · 2025Review
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10 authors.
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Abstract
Direct observation of tumor-immune interactions is unlikely in tumors with currently available technology, but computational simulations based on clinical data can provide insight to test hypotheses. It is hypothesized that patterns of collagen evolve as a mechanism of immune escape, but the exact nature of immune-collagen interactions is poorly understood. Spatial data quantifying collagen fiber alignment in squamous cell carcinomas indicates that late-stage disease is associated with highly aligned fibers. Our computational modeling framework discriminates between two hypotheses: immune cell migration that moves (1) parallel or (2) perpendicular to collagen fiber orientation. The modeling recapitulates immune-extracellular matrix interactions where collagen patterns provide immune protection, leading to an emergent inverse relationship between disease stage and immune coverage. Here, computational modeling provides important mechanistic insights by defining a kernel cell-cell interaction function that considers a spectrum of local (cell-scale) to global (tumor-scale) spatial interactions. Short-range interaction kernels provide a mechanism for tumor cell survival under conditions with strong Allee effects, while asymmetric tumor-immune interaction kernels lead to poor immune response. Thus, the length scale of tumor-immune interaction kernels drives tumor growth and infiltration.
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