Evidence map›Paper›PMID 39349436›Full record

ArticleCell death & disease2024

Association of autosomal mosaic chromosomal alterations with risk of bladder cancer in Chinese adults: a prospective cohort study.

Mingyu Song, Yuting Han, Yuxuan Zhao, Jun Lv, Canqing Yu, Pei Pei, Ling Yang, Iona Y Millwood, Robin G Walters, Yiping Chen and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Mingyu SongDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.
Yuting HanDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.
Yuxuan ZhaoDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.
Jun LvDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.
Canqing YuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.ORCID http://orcid.org/0000-0002-0019-0014
Pei PeiPeking University Center for Public Health and Epidemic Preparedness & Response, Beijing, 100191, China.
Ling YangClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Iona Y MillwoodClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Robin G WaltersClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID http://orcid.org/0000-0002-9179-0321
Yiping ChenClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Huaidong DuClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Xiaoming YangClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Wei YaoNCDs Prevention and Control Department, Tongxiang CDC, Tongxiang, Zhejiang, China.
Junshi ChenChina National Center for Food Safety Risk Assessment, Beijing, China.
Zhengming ChenClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID http://orcid.org/0000-0001-6423-105X
Giulio GenoveseProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Chikashi TeraoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Liming LiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.
Dianjianyi SunDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China. dsun1@bjmu.edu.cn.ORCID http://orcid.org/0000-0003-3651-6693
China Kadoorie Biobank Collaborative Group

Funding

Chinese Ministry of Science and Technology | Department of S and T for Social Development (Department of S&T for Social Development) 2011BAI09B01National Natural Science Foundation of China (National Science Foundation of China) 82192901,82192904, 82192900，81390540, 91846303, 81941018Wellcome TrustWellcome Trust (Wellcome) 212946/Z/18/Z, 202922/Z/16/Z, 104085/Z/14/Z, 088158/Z/09/Z
6 · The paper itself

Abstract

Little is known about the prospective association between autosomal mosaic chromosomal alterations (mCAs), a group of large-scale somatic mutations on autosomes, and bladder cancer. Here we utilized data from 99,877 participants who were free of physician-diagnosed cancer at baseline (2004-2008) of the China Kadoorie Biobank to estimate the associations between autosomal mCAs and bladder cancer (ICD-10: C67). A total of 2874 autosomal mCAs events among 2612 carriers (2.6%) were detected. After a median follow-up of 12.4 years, we discovered that participants with all autosomal mCAs exhibited higher risks of bladder cancer, with a multivariable-adjusted hazard ratio (HR) (95% confidence interval [CI]) of 2.60 (1.44, 4.70). The estimate of such association was even stronger for mosaic loss events (HR [95% CI]: 6.68 [2.92, 15.30]), while it was not significant for CN-LOH events. Both expanded (cell fraction ≥10%) and non-expanded autosomal mCAs, as well as mosaic loss, were associated with increased risks of bladder cancer. Of interest, physical activity (PA) significantly modified the associations of autosomal mCAs and mosaic loss (P

Indexed as

Chromosome AberrationsMosaicismUrinary Bladder NeoplasmsAdultAgedChinaEast Asian PeopleFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedProspective StudiesRisk Factors

Identifiers

PMID39349436
PMCPMC11443067

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.