Evidence map›Paper›PMID 39349308›Full record

Observational studyAJNR. American journal of neuroradiology2025

Thrombectomy Alone or Alongside Intravenous Thrombolysis in Managing Acute Ischemic Stroke Caused by Basilar Artery Occlusion: A Multicenter Observational Study.

Mo Yang, Yue-Zhou Cao, Peng-Hua Lv, Yasuo Ding, Zhensheng Liu, Zhenyu Jia, Lin-Bo Zhao, Chuan Xu, Hai-Bin Shi, Sheng Liu

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mo YangFrom the Department of Interventional Radiology (M.Y., Y.-Z.C., Z.J., L.-B.Z., H.-B.S, S.L.), The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yue-Zhou CaoFrom the Department of Interventional Radiology (M.Y., Y.-Z.C., Z.J., L.-B.Z., H.-B.S, S.L.), The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Peng-Hua LvDepartment of Interventional Radiology (P.H.L., C.X.), Northern Jiangsu People's Hospital, Yangzhou, China.ORCID 0000-0001-6070-7727
Yasuo DingDepartment of Neurosurgery (Y.D.), Taizhou People's Hospital, Taizhou, China.
Zhensheng LiuDepartment of Interventional Radiology (Z.L.), The Affiliated Hospital of Yangzhou University, Yangzhou, China.
Zhenyu JiaFrom the Department of Interventional Radiology (M.Y., Y.-Z.C., Z.J., L.-B.Z., H.-B.S, S.L.), The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Lin-Bo ZhaoFrom the Department of Interventional Radiology (M.Y., Y.-Z.C., Z.J., L.-B.Z., H.-B.S, S.L.), The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID 0000-0002-1578-6566
Chuan XuDepartment of Interventional Radiology (P.H.L., C.X.), Northern Jiangsu People's Hospital, Yangzhou, China.
Hai-Bin ShiFrom the Department of Interventional Radiology (M.Y., Y.-Z.C., Z.J., L.-B.Z., H.-B.S, S.L.), The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID 0000-0003-1293-5789
Sheng LiuFrom the Department of Interventional Radiology (M.Y., Y.-Z.C., Z.J., L.-B.Z., H.-B.S, S.L.), The First Affiliated Hospital of Nanjing Medical University, Nanjing, China liusheng@njmu.edu.cn.ORCID 0000-0002-4058-4413

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeIt remains unclear whether the combination of endovascular treatment (EVT) with intravenous thrombolysis (IVT) results in a more favorable functional outcome than EVT alone in managing cases of acute ischemic stroke (AIS) caused by basilar artery occlusion (BAO). Thus, this study aimed to compare the outcomes of 2 approaches-direct endovascular treatment (DEVT) and bridging therapy (IVT plus EVT)-in patients with acute BAO presenting within 4.5 hours of stroke onset. MATERIALS AND

methodsThis multicenter retrospective cohort study included 153 patients with acute BAO presenting within 4.5 hours of stroke onset. Of these patients, 65 (42.5%) and 88 (57.5%) underwent DEVT and bridging therapy, respectively. The primary outcome was defined as good functional outcome (mRS, 0-3) at 90 days. Additionally, preoperative clinical features, thrombectomy attempts, successful reperfusion rates, incidences of symptomatic intracranial hemorrhage (sICH), and mortality were compared between the 2 groups.

resultsAt 90 days, the rate of good functional outcome was comparable between the DEVT (44.6%) and bridging-therapy (39.8%) groups (adjusted odds ratio [aOR], 1.12; 95% CI, 0.55-2.31;

conclusionsIn patients with BAO-induced AIS, DEVT demonstrates a comparable functional outcome to bridging therapy within 4.5 hours of symptom onset, but IVT reduces the number of thrombectomy attempts.

Indexed as

Ischemic StrokeThrombectomyThrombolytic TherapyVertebrobasilar InsufficiencyAgedAged, 80 and overCombined Modality TherapyEndovascular ProceduresFemaleFibrinolytic AgentsHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeFibrinolytic Agents

Identifiers

PMID39349308
PMCPMC11979831

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.