Evidence map›Paper›PMID 39349303›Full record

ArticleBMJ case reports2024

Baclofen overdose with unique cardiovascular effects.

Cain M Dudek, Christopher H Yee, Max Greenberg, Stewart C McCarver

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cain M DudekPenn State College of Medicine, Hershey, Pennsylvania, USA.
Christopher H YeePenn State College of Medicine, Hershey, Pennsylvania, USA.
Max GreenbergPenn State College of Medicine, Hershey, Pennsylvania, USA.
Stewart C McCarverDepartment of Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA smccarver@pennstatehealth.psu.edu.ORCID http://orcid.org/0009-0004-5963-1824

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

case presentationA woman in her 70s was found unresponsive and brought to our hospital with respiratory distress, cardiomyopathy and volatile alternation between hypotension and hypertension. She was intubated and admitted to intensive care for supportive treatment of suspected baclofen overdose. She gradually recovered and was discharged 10 days after presentation. Laboratory testing confirmed baclofen overdose.

conclusionThis case illustrates the classic features of baclofen toxicity but also includes unusual features including ST elevations on ECG and apical ballooning on echocardiogram. Lack of immediate laboratory testing can be a significant diagnostic challenge, so a high index of suspicion is needed to definitively diagnose baclofen overdose. Furthermore, haemodynamic volatility requires careful and frequent re-evaluation of treatment, so early recognition and anticipation of complications are essential for effective management of this life-threatening condition.

Indexed as

BaclofenDrug OverdoseAgedEchocardiographyElectrocardiographyFemaleHumansMuscle Relaxants, CentralBaclofenMuscle Relaxants, CentralAdult intensive careCardiovascular systemPoisoningToxicology

Identifiers

PMID39349303
PMCPMC11448130

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.