Evidence map›Paper›PMID 39349060›Full record

ArticleeNeuro2024

Role of the Nucleus Accumbens in Signaled Avoidance Actions.

Ji Zhou, Sebastian Hormigo, Muhammad S Sajid, Manuel A Castro-Alamancos

Abstract read
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ji ZhouDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut 06001.
Sebastian HormigoDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut 06001.
Muhammad S SajidDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut 06001.
Manuel A Castro-AlamancosDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut 06001.ORCID https://orcid.org/0000-0002-2916-9585

Funding

Sensory pathways for stimulus detection during behaviorR35NS097272 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CASTRO-ALAMANCOS, MANUEL A · 2017 to 2024
$4.3M
Neural mechanisms of active avoidance behaviorR01NS104810 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CASTRO-ALAMANCOS, MANUEL A · 2018 to 2022
$2.8M
NINDS NIH HHS R01 NS104810NINDS NIH HHS R35 NS097272
6 · The paper itself

Abstract

Animals, humans included, navigate their environments guided by sensory cues, responding adaptively to potential dangers and rewards. Avoidance behaviors serve as adaptive strategies in the face of signaled threats, but the neural mechanisms orchestrating these behaviors remain elusive. Current circuit models of avoidance behaviors indicate that the nucleus accumbens (NAc) in the ventral striatum plays a key role in signaled avoidance behaviors, but the nature of this engagement is unclear. Evolving perspectives propose the NAc as a pivotal hub for action selection, integrating cognitive and affective information to heighten the efficiency of both appetitive and aversive motivated behaviors. To unravel the engagement of the NAc during active and passive avoidance, we used calcium imaging fiber photometry to examine NAc GABAergic neuron activity in

Indexed as

Avoidance LearningGABAergic NeuronsNucleus AccumbensOptogeneticsAnimalsMaleMiceMice, Inbred C57BLMice, Transgenicavoidancemidbrainmovementnucleus accumbenssensorimotor

Identifiers

PMID39349060
PMCPMC11613310

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.