Evidence map›Paper›PMID 39349056›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

The Nociceptor Primary Cilium Contributes to Mechanical Nociceptive Threshold and Inflammatory and Neuropathic Pain.

Lindsey A Fitzsimons, Larissa Staurengo-Ferrari, Eugen V Khomula, Oliver Bogen, Dionéia Araldi, Ivan J M Bonet, Paul G Green, Ethan E Jordan, Finn Sclafani, Connor E Nowak and 4 more

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The nociceptor primary cilium.Brain : a journal of neurology · 2026
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lindsey A FitzsimonsDeparment of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, Maine 04005.ORCID 0000-0002-1949-6849
Larissa Staurengo-FerrariDepartment of Oral and Maxillofacial Surgery, UCSF Pain and Addiction Research Center, University of California San Francisco, San Francisco 94115.
Eugen V KhomulaDepartment of Oral and Maxillofacial Surgery, UCSF Pain and Addiction Research Center, University of California San Francisco, San Francisco 94115.ORCID 0000-0003-0221-2237
Oliver BogenDepartment of Oral and Maxillofacial Surgery, UCSF Pain and Addiction Research Center, University of California San Francisco, San Francisco 94115.
Dionéia AraldiDepartment of Oral and Maxillofacial Surgery, UCSF Pain and Addiction Research Center, University of California San Francisco, San Francisco 94115.ORCID 0000-0001-8379-2901
Ivan J M BonetDepartment of Oral and Maxillofacial Surgery, UCSF Pain and Addiction Research Center, University of California San Francisco, San Francisco 94115.
Paul G GreenDepartment of Oral and Maxillofacial Surgery, UCSF Pain and Addiction Research Center, University of California San Francisco, San Francisco 94115.
Ethan E JordanDeparment of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, Maine 04005.
Finn SclafaniCenter for Excellence in the Neurosciences, University of New England, Biddeford, Maine 04005.
Connor E NowakCenter for Excellence in the Neurosciences, University of New England, Biddeford, Maine 04005.
Julie K MoultonCenter for Excellence in the Neurosciences, University of New England, Biddeford, Maine 04005.
Geoffrey K GanterCenter for Excellence in the Neurosciences, University of New England, Biddeford, Maine 04005.
Jon D LevineDepartment of Oral and Maxillofacial Surgery, UCSF Pain and Addiction Research Center, University of California San Francisco, San Francisco 94115.ORCID 0000-0003-0681-5545
Kerry L TuckerDeparment of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, Maine 04005 ktucker2@une.edu.ORCID 0000-0001-7671-8690

Funding

Tissue resident macrophages in sensory ganglia: function and impact on nociceptionP20GM103643 · NIGMS · UNIVERSITY OF NEW ENGLAND · PI MENG, IAN D · 2012 to 2021
$20.9M
Chronic Chemotherapy Peripheral Neuropathy: Role of Neuroplasticity and StressR01CA250017 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVINE, JON DAVID · 2019 to 2023
$3.3M
Hyaluronan signaling to nociceptors in inflammatory painR01AR075334 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVINE, JON DAVID · 2019 to 2023
$3.0M
Investigation of Armadillo/ß-catenin Mechanisms Influencing Nociceptive Sensitivity in DrosophilaR15NS131952 · NINDS · UNIVERSITY OF NEW ENGLAND · PI GEOFFREY GANTER · 2023 to 2026
$959k
Role of Nociceptor Primary Cilia in Inflammatory and Neuropathic PainR21NS130249 · NINDS · UNIVERSITY OF NEW ENGLAND · PI TUCKER, KERRY L · 2022 to 2022
$391k
NCI NIH HHS R01 CA250017NIAMS NIH HHS R01 AR075334NIGMS NIH HHS P20 GM103643NINDS NIH HHS R15 NS131952NINDS NIH HHS R21 NS130249
6 · The paper itself

Abstract

The primary cilium, a single microtubule-based organelle protruding from the cell surface and critical for neural development, also functions in adult neurons. While some dorsal root ganglion neurons elaborate a primary cilium, whether it is expressed by and functional in nociceptors is unknown. Recent studies have shown the role of Hedgehog, whose canonical signaling is primary cilium dependent, in nociceptor sensitization. We establish the presence of primary cilia in soma of rat nociceptors, where they contribute to mechanical threshold, prostaglandin E

Indexed as

CiliaNeuralgiaNociceptorsRats, Sprague-DawleyAnimalsDinoprostoneFemaleGanglia, SpinalHedgehog ProteinsHyperalgesiaInflammationMalePaclitaxelPain ThresholdRatsDinoprostoneHedgehog ProteinsPaclitaxelchemotherapy-induced neuropathy; Hedgehoghyperalgesiainflammationnociceptorprimary cilium

Identifiers

PMID39349056
PMCPMC11580782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.