Evidence map›Paper›PMID 39348606›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2025

Lisa Werr, Christoph Bartenhagen, Carolina Rosswog, Maria Cartolano, Catherine Voegele, Alexandra Sexton-Oates, Alex Di Genova, Angela Ernst, Yvonne Kahlert, Nadine Hemstedt and 26 more

Abstract read
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Lisa WerrDepartment of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Cologne, Germany.ORCID 0000-0002-3697-4136
Christoph BartenhagenDepartment of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Cologne, Germany.ORCID 0000-0002-2522-1454
Carolina RosswogDepartment of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Cologne, Germany.ORCID 0000-0002-8855-6198
Maria CartolanoCenter for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne, Cologne, Germany.
Catherine VoegeleRare Cancers Genomics Team (RCG), Genomic Epidemiology Branch (GEM), International Agency for Research on Cancer/World Health Organisation (IARC/WHO), Lyon, France.ORCID 0000-0002-9592-8869
Alexandra Sexton-OatesRare Cancers Genomics Team (RCG), Genomic Epidemiology Branch (GEM), International Agency for Research on Cancer/World Health Organisation (IARC/WHO), Lyon, France.
Alex Di GenovaRare Cancers Genomics Team (RCG), Genomic Epidemiology Branch (GEM), International Agency for Research on Cancer/World Health Organisation (IARC/WHO), Lyon, France.ORCID 0000-0002-3120-9283
Angela ErnstInstitute of Medical Statistics and Computational Biology, Medical Faculty, University of Cologne, Cologne, Germany.ORCID 0000-0003-2375-1889
Yvonne KahlertDepartment of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Cologne, Germany.ORCID 0009-0006-0556-0439
Nadine HemstedtDepartment of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Cologne, Germany.
Stefanie HöppnerDepartment of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Cologne, Germany.ORCID 0000-0002-2318-1874
Audrey Mansuet LupoDepartment of Pathology, Assistance Publique-Hôpitaux de Paris, Cochin Hospital, Paris Cité University, Paris, France.ORCID 0000-0002-7196-2114
Giuseppe PelosiDepartment of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.ORCID 0000-0003-4725-4692
Luka BrcicDiagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.ORCID 0000-0002-9098-8416
Mauro PapottiDepartment of Oncology, University of Turin, Torino, Italy.
Julie GeorgeDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Graziella BoscoDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0001-6601-4518
Alexander QuaasInstitute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Laura H TangDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.
Kenneth RobzykSloan Kettering Institue, Memorial Sloan Kettering Cancer Center, New York, NY.
Kyuichi KadotaMolecular Oncologic Pathology, Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, Takamatsu, Japan.
Mee Sook RohDepartment of Pathology, Dong-A University College of Medicine, Busan, South Korea.ORCID 0000-0002-3016-2989
Rachel E FanaroffUniversity of Maryland School of Maryland, Baltimore, MD.ORCID 0009-0000-1451-000X
Christina J FalconSloan Kettering Institue, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-9143-1639
Reinhard BüttnerInstitute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0001-8806-4786
Sylvie LantuejoulDepartment of Biopathology, Centre de Lutte Contre le Cancer UNICANCER Léon Bérard, Grenoble Alpes University, Lyon, France.
Natasha RekhtmanDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-5801-3144
Charles M RudinThoracic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-5204-3465
William D TravisDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-6105-182X
Nicolas AlcalaRare Cancers Genomics Team (RCG), Genomic Epidemiology Branch (GEM), International Agency for Research on Cancer/World Health Organisation (IARC/WHO), Lyon, France.ORCID 0000-0002-5961-5064
Lynnette Fernandez-CuestaRare Cancers Genomics Team (RCG), Genomic Epidemiology Branch (GEM), International Agency for Research on Cancer/World Health Organisation (IARC/WHO), Lyon, France.ORCID 0000-0002-9290-4589
Matthieu FollRare Cancers Genomics Team (RCG), Genomic Epidemiology Branch (GEM), International Agency for Research on Cancer/World Health Organisation (IARC/WHO), Lyon, France.ORCID 0000-0001-9006-8436
Martin PeiferCenter for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne, Cologne, Germany.ORCID 0000-0002-5243-5503
Roman K ThomasDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Matthias FischerDepartment of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Cologne, Germany.ORCID 0000-0003-1363-1242
Lung NEN Network

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748World Health Organization 001
6 · The paper itself

Abstract

purposeThe clinical course of pulmonary carcinoids ranges from indolent to fatal disease, suggesting that specific molecular alterations drive progression toward the fully malignant state. A similar spectrum of clinical phenotypes occurs in pediatric neuroblastoma, in which activation of telomerase reverse transcriptase (

methods

resultsSimilar to neuroblastoma,

conclusionOur data demonstrate that high

Indexed as

Carcinoid TumorLung NeoplasmsTelomeraseAdultAgedBiomarkers, TumorFemaleHumansKaplan-Meier EstimateMaleMiddle AgedPrognosisYoung AdultBiomarkers, TumorTelomeraseTERT protein, human

Identifiers

PMID39348606
PMCPMC11709002

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.