ArticleProceedings of the National Academy of Sciences of the United States of America2024
TCA metabolism regulates DNA hypermethylation in LPS and
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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Who cites it
19 citing papers in PubMed.
- Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026Review
- Epigenetics-mediated pathological alterations and their diagnostic and therapeutic potential in sepsis-associated acute kidney injury.Clinical epigenetics · 2026Review
- An integrated in silico and in vitro approach to decipher the anti-tubercular potential of novel thiazetidine scaffolds.Journal of computer-aided molecular design · 2026Article
- Review
- Trained immunity modulators: A new frontier in immunoregulation and disease intervention.Journal of advanced research · 2026Review
- Immune endotypes in tuberculosis: Keys to decoding disease complexity.Journal of internal medicine · 2026Review
- Metabolic and post-translational modifications in sepsis-associated immune dysfunction: a conceptual framework.Frontiers in immunology · 2026Review
- Interactions between Innate Immune Memory and the Central Nervous System.Neuroimmunomodulation · 2026Review
- Review
- Nutritional Deficiencies and Management in Tuberculosis: Pharmacotherapeutic and Clinical Implications.Nutrients · 2025Review
- Immunogenic cell death biomarkers for sepsis diagnosis and mechanism via integrated bioinformatics.Scientific reports · 2025Article
- Multi-Omics Integration Reveals Mitochondrial Gene Regulation as a Determinant of Tuberculosis Susceptibility: A Mendelian Randomization Approach.Biomedicines · 2025Article
- Increased autophagy activity regulated by LC3B gene promoter DNA methylation is associated with progression to active pulmonary tuberculosis disease.Respiratory research · 2025Article
- Characterization of Rationally Designed CRISPR/Cas9-Based DNA Methyltransferases with Distinct Methyltransferase and Gene Silencing Activities in Human Cell Lines and Primary Human T Cells.ACS synthetic biology · 2025Article
- Inclusion of patient-centered, non-microbiological endpoints and biomarkers in tuberculosis drug trials.Frontiers in antibiotics · 2025Review
- Experimental dissection of tuberculosis protective immunity: a human perspective.Frontiers in cellular and infection microbiology · 2025Review
- Linking metabolic and epigenetic changes in immune tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- MethylGPT: a foundation model for the DNA methylome.bioRxiv : the preprint server for biology · 2024Article
- TCA metabolism regulates DNA hypermethylation in LPS andProceedings of the National Academy of Sciences of the United States of America · 2024Article
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Authors and funding
20 authors.
AbhimanyuDepartment of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0001-7888-8722
Santiago Carrero LonglaxDepartment of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0001-8731-0105
Tomoki NishiguchiDepartment of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030.
Malik LadkiDepartment of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0001-8735-5696
Daanish SheikhDepartment of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030.
Amera L MartinezDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
Emily M MaceDepartment of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032.ORCID 0000-0003-0226-7393
Sandra L GrimmDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-0682-3134
Thaleia CaldwellDepartment of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030.
Alexandra Portillo VarelaDepartment of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030.
Rajagopal V SekharTranslational Metabolism Unit, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030.
Anna M MandalakasDepartment of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030.
Mandla MlotshwaThe Aurum institute, Johannesburg 2006, South Africa.ORCID 0000-0002-5534-1051
Sibuse GinidzaThe Aurum institute, Johannesburg 2006, South Africa.
Jeffrey D CirilloCenter for Airborne Pathogen Research and Imaging, Texas A&M College of Medicine, Bryan, TX 77843.ORCID 0000-0003-3058-2702
Robert S WallisThe Aurum institute, Johannesburg 2006, South Africa.
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen 6525, Netherlands.
Reinout van CrevelDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen 6525, Netherlands.
Cristian CoarfaDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030.
Andrew R DiNardoDepartment of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030.
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9MTranslational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2019 to 2026
$14.7MProject 2: Disparities-Aware Classifiers for Maternal and Infant HealthP50MD015496 · NIMHD · BAYLOR COLLEGE OF MEDICINE · PI SYMANSKI, ELAINE · 2020 to 2024
$7.2MIntegrated Networks of Scholars in Global Health Research Training (INSIGHT) Program D43TW012274 · FIC · UNIVERSITY OF MARYLAND BALTIMORE · PI Olakunle Alonge, Jessica Griffin Burke · 2022 to 2026
$6.5MPost-TB epigenetic scars' impact on long-term inflammation, immunity and mortalityR01AI170774 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI Andrew R DiNardo · 2023 to 2026
$2.9MQuantifiable stool-based TB PCR to Improve Diagnostics and Treatment MonitoringR01AI137527 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MANDALAKAS, ANNA M · 2019 to 2022
$2.7MINTERCEPTR01AI165721 · NIAID · STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM I.O. · PI Guy Thwaites, Reinout Van Crevel · 2022 to 2026
$2.7MCommon Post-Infectious Premature Epigenetic AgingR01AG078268 · NIA · BAYLOR COLLEGE OF MEDICINE · PI Andrew R DiNardo · 2023 to 2026
$2.5MPersistent DNA Hyper-Methylation of the IFN-γ Signaling Pathway During TuberculosisK23AI141681 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI DINARDO, ANDREW R · 2019 to 2023
$947kMyD88-dependent mechanisms of Helicobacter pylori-induced gastric cancer progressionR21CA210227 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OBONYO, MARYGORRET · 2017 to 2018
$371kBill and Melinda Gates Foundation (GF) OPP1127276-2015Cancer Prevention and Research Institute of Texas (CPRIT) RP210227Cordis (Community Research and Development Information Service) 101007873DOD | OSD | Defense Technical Information Center (DTIC) W81XWH1910026EC | H2020 | ERA-LEARN | European and Developing Countries Clinical Trials Partnership (EDCTP) RIA2018CO-2514FIC NIH HHS D43 TW012274HHS | NIH | Fogarty International Center (FIC) D43TW012274HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 1R01AG078268-01A1HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 1R01AI70774-01A1HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI141681-04HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) P30ES030285 1P42ES0327725HHS | NIH | National Institute on Minority Health and Health Disparities (NIMHD) P50MD015496HHS | NIH | NHLBI | Division of Intramural Research (DIR) U01GH00227847HHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID) R01AG078268HHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID) R01AI137527HHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID) R01AI165721National Cancer Center (NCC) P30CA125123NCI NIH HHS P30 CA125123NIAID NIH HHS K23 AI141681NIAID NIH HHS R01 AI137527NIAID NIH HHS R01 AI165721NIAID NIH HHS R01 AI170774NIA NIH HHS R01 AG078268NIEHS NIH HHS P30 ES030285NIMHD NIH HHS P50 MD015496
Abstract
Severe and chronic infections, including pneumonia, sepsis, and tuberculosis (TB), induce long-lasting epigenetic changes that are associated with an increase in all-cause postinfectious morbidity and mortality. Oncology studies identified metabolic drivers of the epigenetic landscape, with the tricarboxylic acid (TCA) cycle acting as a central hub. It is unknown if the TCA cycle also regulates epigenetics, specifically DNA methylation, after infection-induced immune tolerance. The following studies demonstrate that lipopolysaccharide and
Indexed as
Citric Acid CycleDNA MethylationImmune ToleranceLipopolysaccharidesMycobacterium tuberculosisTuberculosisAnimalsEpigenesis, GeneticEverolimusHumansMiceSuccinatesSuccinic AcidEverolimusitaconic acidLipopolysaccharidesSuccinatesSuccinic AcidDNA methylationimmune toleranceRheostatsepsistuberculosis
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