Evidence map›Paper›PMID 39348242›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Selenium Attenuates Radiation Colitis by Regulating cGAS-STING Signaling.

Qian Xue, Haoqiang Lai, Haimei Zhang, Guizhen Li, Fen Pi, Qifeng Wu, Siwei Liu, Fang Yang, Tianfeng Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  6. Review
  7. Review
  8. Review
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  10. Article
  11. Review
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  15. Review
  16. Article
  17. Selenium Attenuates Radiation Colitis by Regulating cGAS-STING Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qian XueDepartment of Radiation Oncology of Puning People's Hospital, Department of Chemistry of Jinan University, State Key Laboratory of Bioactive Molecules and Druggalibility Assessment, MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangdong, China.
Haoqiang LaiDepartment of Radiation Oncology of Puning People's Hospital, Department of Chemistry of Jinan University, State Key Laboratory of Bioactive Molecules and Druggalibility Assessment, MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangdong, China.
Haimei ZhangDepartment of Radiation Oncology of Puning People's Hospital, Department of Chemistry of Jinan University, State Key Laboratory of Bioactive Molecules and Druggalibility Assessment, MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangdong, China.
Guizhen LiDepartment of Radiation Oncology of Puning People's Hospital, Department of Chemistry of Jinan University, State Key Laboratory of Bioactive Molecules and Druggalibility Assessment, MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangdong, China.
Fen PiDepartment of Radiation Oncology of Puning People's Hospital, Department of Chemistry of Jinan University, State Key Laboratory of Bioactive Molecules and Druggalibility Assessment, MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangdong, China.
Qifeng WuDepartment of Radiation Oncology of Puning People's Hospital, Department of Chemistry of Jinan University, State Key Laboratory of Bioactive Molecules and Druggalibility Assessment, MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangdong, China.
Siwei LiuDepartment of Radiation Oncology of Puning People's Hospital, Department of Chemistry of Jinan University, State Key Laboratory of Bioactive Molecules and Druggalibility Assessment, MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangdong, China.
Fang YangDepartment of Radiation Oncology of Puning People's Hospital, Department of Chemistry of Jinan University, State Key Laboratory of Bioactive Molecules and Druggalibility Assessment, MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangdong, China.
Tianfeng ChenDepartment of Radiation Oncology of Puning People's Hospital, Department of Chemistry of Jinan University, State Key Laboratory of Bioactive Molecules and Druggalibility Assessment, MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangdong, China.ORCID 0000-0001-6953-1342

Funding

National Key R&D Program of China 2023YFC3402800National Natural Science Foundation of China 32101044National Natural Science Foundation of China 32171296National Science Fund for Distinguished Young Scholars 82225025
6 · The paper itself

Abstract

Radiation colitis is one of the most common complications in patients undergoing pelvic radiotherapy and there is no effective treatment in the clinic. Therefore, searching for effective agents for the treatment of radiation colitis is urgently needed. Herein, it is found that the essential element selenium (Se) is protective against radiation colitis through inhibiting X-ray-induced apoptosis, cell cycle arrest, and inflammation with the involvement of balancing the generation of reactive oxygen species after the irradiation. Mechanistically, Se, especially for selenium nanoparticles (SeNPs), induced selenoprotein expression and then functioned to effectively restrain DNA damage response, which reduced X-ray-induced intestinal injury. Additionally, SeNPs treatment also restrained the cyclic GMP-AMP synthas (cGAS)- stimulator of interferon genes (STING)-TBK1-IRF3 signaling pathway cascade, thereby blocking the transcription of inflammatory cytokine gene, IL-6 and TNF-α, and thus alleviating inflammation. Moreover, inducing selenoprotein expression, such as GPX4, with SeNPs in vivo can regulate intestinal microenvironment immunity and gut microbiota to attenuate radiation-induced colitis by inhibiting oxidative stress and maintaining microenvironment immunity homeostasis. Together, these results unravel a previously unidentified modulation role that SeNPs restrained radiation colitis with the involvement of inducing selenoprotein expression but suppressing cGAS-STING-TBK1-IRF3 cascade.

Indexed as

ColitisMembrane ProteinsNucleotidyltransferasesSeleniumSignal TransductionAnimalsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDisease Models, AnimalMiceMice, Inbred C57BLSTING ProteincGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMembrane ProteinsNucleotidyltransferasesSeleniumSting1 protein, mouseSTING ProteincGAS‐STINGDNA damageradiation colitisROSselenium

Identifiers

PMID39348242
PMCPMC11600249

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.