Evidence map›Paper›PMID 39348010›Full record

ArticleJournal of materials science. Materials in medicine2024

Selective mycobacterial capture with ultraviolet-polymerized poly-dimethyldiallyl chloride functionalized surfaces.

Xuesong Jiang, Bonolo S P Mathekga, Digvijay Singh, Devin Coon, Anjana Sinha, Derek Armstrong, Soumyadipta Acharya, Hai-Quan Mao, Yukari C Manabe

Abstract read
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In one paragraph

Article in Journal of materials science. Materials in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xuesong JiangDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, 21218, MD, USA.
Bonolo S P Mathekga *Center for Bioengineering Innovation and Design, Johns Hopkins University, Baltimore, 21218, MD, USA. bmathek1@jhu.edu.ORCID http://orcid.org/0009-0006-8345-6311
Digvijay Singh *Center for Bioengineering Innovation and Design, Johns Hopkins University, Baltimore, 21218, MD, USA.
Devin CoonDepartments of Plastic and Reconstructive Surgery, School of Medicine, Johns Hopkins University, Baltimore, 21205, MD, USA.
Anjana SinhaCenter for Bioengineering Innovation and Design, Johns Hopkins University, Baltimore, 21218, MD, USA.
Derek ArmstrongDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 21205, MD, USA.
Soumyadipta AcharyaCenter for Bioengineering Innovation and Design, Johns Hopkins University, Baltimore, 21218, MD, USA.
Hai-Quan MaoDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, 21218, MD, USA. hmao@jhu.edu.
Yukari C ManabeDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 21205, MD, USA. ymanabe@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) is the top cause of death from a single infectious pathogen after COVID-19. Despite molecular diagnostic advances, two-thirds of the 10 million annual TB cases are still diagnosed using direct smear microscopy which has ~50% sensitivity. To increase the analytical performance of smear microscopy, we developed and characterized a novel polymer (Polydiallyldimethylammonium chloride [PDADMAC]) engraftment on inexpensive polystyrene (PS) specifically functionalized for mycobacterial capture. Engraftment is achieved via UV photopolymerization of DADMAC monomer on plasma-activated PS. The platform was tested on sputum from presumptive TB cases in Kampala, Uganda (n = 50), with an increased overall sensitivity of 81.8% (27/33) vs. fluorescent smear microscopy 57% (19/33) compared to a molecular (Cepheid GeneXpert MTB/RIF) gold standard. Frugal smear diagnostic innovation that is rapid and does not require dedicated instrumentation may offer an important solution to bridge the TB diagnostic gap.

Indexed as

Ultraviolet RaysCOVID-19HumansMycobacterium tuberculosisPolyethylenesPolymerizationPolymersPolystyrenesQuaternary Ammonium CompoundsSARS-CoV-2SputumSurface PropertiesTuberculosisPolyethylenesPolymerspoly-N,N-dimethyl-N,N-diallylammonium chloridePolystyrenesQuaternary Ammonium Compounds

Identifiers

PMID39348010
PMCPMC11442618

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.