Role of gadoxetic acid-enhanced MRI in the differential diagnosis of chemotherapy-induced focal nodular hyperplasia-like lesions and liver metastases in patients with colorectal cancer.

Yuan-Yuan Chen, Ming-Liang Wang, Yi Li, Jun Li, Li Yang, Ying Ding, Meng-Su Zeng

Abstract read

In one paragraph

Article in Abdominal radiology (New York), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuan-Yuan ChenDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Ming-Liang WangDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Yi LiDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Jun LiDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Li YangDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Ying DingDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China. ding.ying@zs-hospital.sh.cn.

Meng-Su ZengDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Funding

Excellent Talent Program of Zhongshan Hospital of Fudan University 2019ZSGG23Shanghai Municipal Key Clinical Specialty shslczdzk03202the National Science Foundation for Young Scientists of China Grant No. 81701682

6 · The paper itself

Abstract

purposeTo describe the gadoxetic acid-enhanced magnetic resonance imaging (MRI) features and follow-up changes of hepatic focal nodular hyperplasia (FNH)-like lesions induced by chemotherapy in patients with colorectal cancer (CRC) and the differential diagnosis of FNH-like lesions and liver metastases.

methodsWe retrospectively analyzed the data of patients with CRC who received chemotherapy and gadoxetic-enhanced MRI at our hospital. Based on imaging features and pathological findings, the patients were classified into two groups: FNH-like lesions and liver metastases. Two abdominal radiologists reviewed and compared the signal intensities of all images in each phase for both groups. The characteristics of the FNH-like lesions in the hepatobiliary phase were evaluated, and changes in size of lesions were monitored.

resultsThirty patients with 82 FNH-like lesions and 30 with 49 liver metastases following chemotherapy were included in the study. All MRI findings were statistically significantly different between the two groups (p < 0.05). In FNH-like lesions, three enhancement patterns were observed in the hepatobiliary phase: hyperintense/isointense (18.3%), heterogeneous hyperintense (8.5%), and ring-like enhancement (73.2%). The median time from completion of chemotherapy to development of FNH-like lesions was 31 months. During 4-87 months of follow-up, 27 patients with 73 lesions showed the following outcomes: 41 lesions (56.16%) showed stability, 21 lesions (28.77%) growth, and 11 lesions (15.07%) reduction or disappearance.

conclusionGadoxetic acid-enhanced MRI can distinguish between chemotherapy-induced FNH-like lesions and liver metastases in patients with CRC. The FNH-like lesions exhibited three enhancement patterns in the hepatobiliary phase, and the changes varied during follow-up.

Indexed as

Antineoplastic AgentsColorectal NeoplasmsContrast MediaFocal Nodular HyperplasiaGadolinium DTPAImage EnhancementLiver NeoplasmsMagnetic Resonance ImagingAdultAgedDiagnosis, DifferentialFemaleHumansMaleMiddle AgedRetrospective StudiesAntineoplastic AgentsContrast MediaGadolinium DTPAgadolinium ethoxybenzyl DTPAChemotherapyFocal nodular hyperplasiaGadoxetic acidLiver metastasisMagnetic resonance imaging

Identifiers

PMID39347974

DOI10.14218/JCTH.2023.00265

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.