Evidence map›Paper›PMID 39347611›Full record

ArticleACS applied materials & interfaces2024

Drug-Loaded Mesoporous Polydopamine Nanoparticles in Chitosan Hydrogels Enable Myocardial Infarction Repair through ROS Scavenging and Inhibition of Apoptosis.

Tianhu Wang, Yabin Wang, Yingjie Zhang, Zhiyi Fang, Sulei Li, Zhenghui Gu, Yan Ma, Linghuan Wang, Dong Han, Changyong Wang and 2 more

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. [Advances in hydrogel drug delivery systems for myocardial infarction treatment].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
  11. Targeted drug delivery systems for atherosclerosis.Journal of nanobiotechnology · 2025
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tianhu WangChinese PLA Medical School & Department of Cardiology, The Second Medical Center National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Yabin WangChinese PLA Medical School & Department of Cardiology, The Second Medical Center National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.ORCID 0000-0002-7966-6117
Yingjie ZhangChinese PLA Medical School & Department of Cardiology, The Second Medical Center National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Zhiyi FangSchool of Medicine, Nankai University, Tianjin 300071, China.
Sulei LiChinese PLA Medical School & Department of Cardiology, The Second Medical Center National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Zhenghui GuChinese PLA Medical School & Department of Cardiology, The Second Medical Center National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Yan MaChinese PLA Medical School & Department of Cardiology, The Second Medical Center National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Linghuan WangSchool of Medicine, Nankai University, Tianjin 300071, China.
Dong HanChinese PLA Medical School & Department of Cardiology, The Second Medical Center National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Changyong WangBeijing Institute of Basic Medical Sciences, Beijing 100850, China.
Jin ZhouBeijing Institute of Basic Medical Sciences, Beijing 100850, China.ORCID 0000-0003-3128-407X
Feng CaoChinese PLA Medical School & Department of Cardiology, The Second Medical Center National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.ORCID 0000-0002-1010-6429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we synthesized mesoporous polydopamine nanoparticles (MPDA NPs) using an emulsion-induced interface assembly strategy and loaded epigallocatechin gallate (EGCG) into MPDA NPs via electrostatic attraction to form EGCG@MPDA NPs. In the post myocardial infarction (MI) environment, these interventions specifically aimed to eliminate reactive oxygen species (ROS) and facilitate the repair of MI. We further combined them with a thermosensitive chitosan (CS) hydrogel to construct an injectable composite hydrogel (EGCG@MPDA/CS hydrogel). Utilizing

Indexed as

ApoptosisCatechinChitosanHydrogelsIndolesMyocardial InfarctionNanoparticlesPolymersReactive Oxygen SpeciesAnimalsCell LineFree Radical ScavengersMaleOxidative StressPorosityRatsCatechinChitosanepigallocatechin gallateFree Radical ScavengersHydrogelsIndolespolydopaminePolymersReactive Oxygen SpecieschitosanEGCGinjectable hydrogelmyocardial infarctionPDA

Identifiers

PMID39347611
PMCPMC11566824

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.