Evidence map›Paper›PMID 39347568›Full record

ArticleHead & neck2025

CYLD Alterations Are Associated With Metastasis and Poor Prognosis in Human Papilloma Virus-Positive Head and Neck Cancer.

Zhibin Cui, Hyunseok Kang, Hua Li, Eliot D Lee, Yoon Se Lee, Christopher N Peterson, Steven R Long, Jennifer R Grandis, Daniel E Johnson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Patient-reported outcomes in oropharyngeal cancer: comparing two cohorts with different treatment protocols.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhibin CuiDepartment of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USA.
Hyunseok KangDepartment of Medicine, University of California at San Francisco, San Francisco, California, USA.ORCID 0000-0001-5758-8202
Hua LiDepartment of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USA.
Eliot D LeeDepartment of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USA.
Yoon Se LeeDepartment of Otolaryngology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
Christopher N PetersonDepartment of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USA.
Steven R LongDepartment of Pathology, University of California at San Francisco, San Francisco, California, USA.
Jennifer R GrandisDepartment of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USA.ORCID 0000-0002-1013-8965
Daniel E JohnsonDepartment of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USA.

Funding

Integrating genomics and the protein interactome for HPV+ head and neck cancer therapyR35CA231998 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2018 to 2024
$6.2M
Targeting STAT3 to enhance anti-tumor immunityR01DE028289 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN, JOHNSON, DANIEL E · 2019 to 2023
$3.2M
Implications of Procaspase-8 Mutations in Oral Squamous Cell CarcinomaR01DE024728 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHNSON, DANIEL E · 2016 to 2020
$2.0M
California Tobacco-Related Disease Research Program T29FT0328NCI NIH HHS R35 CA231998NIDCR NIH HHS R01 DE024728NIDCR NIH HHS R01 DE028289NIH HHS R01 DE024728NIH HHS R01DE028289-01A1NIH HHS R35CA231998R01DE028289-01A1
6 · The paper itself

Abstract

backgroundHuman papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is an emerging epidemic and a subset of HPV-positive patients experience aggressive disease with metastases. The CYLD gene is frequently altered in HPV-positive HNSCC, but the role of these alterations in disease progression is poorly understood.

methodsWe identified 11 HPV-positive HNSCC patients with CYLD alterations and assessed their clinical course. We also characterized a unique, HPV-positive, metastatic, HNSCC patient-derived xenograft (PDX).

resultsAll 11 patients developed metastasis with reduced overall survival when compared with metastatic HPV-positive patients with wild-type CYLD. The metastatic PDX harbored a CYLD mutation (S371*) and exhibited reduced expression of connexin 43, a potentially antimetastatic protein. We also investigated the functional impact of the S371* mutation, as well as 2 CYLD mutations from our 11-patient cohort.

conclusionOur findings indicate that alterations in CYLD in HPV-positive HNSCC are associated with metastasis and poor prognosis.

Indexed as

Deubiquitinating Enzyme CYLDHead and Neck NeoplasmsMutationPapillomavirus InfectionsSquamous Cell Carcinoma of Head and NeckAgedAnimalsCarcinoma, Squamous CellFemaleHuman Papillomavirus VirusesHumansMaleMiceMiddle AgedNeoplasm MetastasisPapillomaviridaeCYLD protein, humanDeubiquitinating Enzyme CYLDTumor Suppressor ProteinsCYLDHNSCCHPVmetastasisprognosis

Identifiers

PMID39347568
PMCPMC11845079

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.