Evidence map›Paper›PMID 39347009›Full record

ArticleBiomedical optics express2024

High-speed reflectance confocal microscopy using speckle modulation.

Momoka Sugimura, Kenneth Marcelino, Rafael Romero, Jingwei Zhao, Yongjun Kim, Ameer Nessaee, Kyungjo Kim, Delaney Stratton, Clara Curiel-Lewandrowski, Jason Garfinkel and 2 more

Abstract read
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. PortableBiomedical optics express · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Momoka SugimuraJames C. Wyant College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.
Kenneth MarcelinoJames C. Wyant College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.
Rafael RomeroDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona 85721, USA.
Jingwei ZhaoJames C. Wyant College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.
Yongjun KimDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona 85721, USA.
Ameer NessaeeDepartment of Electrical and Computer Engineering, University of Arizona, Tucson, Arizona 85721, USA.
Kyungjo KimJames C. Wyant College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.
Delaney StrattonCollege of Medicine, University of Arizona, Tucson, Arizona 85721, USA.
Clara Curiel-LewandrowskiCollege of Medicine, University of Arizona, Tucson, Arizona 85721, USA.
Jason GarfinkelArgosMD, Studio City, California 91604, USA.
Gennady RubinsteinArgosMD, Studio City, California 91604, USA.
Dongkyun KangJames C. Wyant College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.

Funding

High-speed, portable reflectance confocal microscope (pRCM) for imaging skin cancerR41CA261214 · NCI · ARGOSMD, INC. · PI KANG, DONGKYUN · 2022 to 2022
$398k
NCI NIH HHS R41 CA261214
6 · The paper itself

Abstract

We developed a spectrally-encoded, line reflectance confocal microscope (RCM) that uses a rotating diffuser to rapidly modulate the illumination speckle pattern. The speckle modulation approach reduced speckle noise while imaging with a spatially coherent light source needed for high imaging speed and cellular resolution. The speckle-modulation RCM device achieved lateral and axial resolutions of 1.1 µm and 2.8 µm, respectively. With an imaging speed of 107 frames/sec, three-dimensional RCM imaging over 300-µm depth was completed within less than 1 second. RCM images of human fingers, forearms, and oral mucosa clearly visualized the characteristic cellular features without any noticeable speckle noise.

Identifiers

PMID39347009
PMCPMC11427182

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.