Evidence map›Paper›PMID 39347001›Full record

ArticleBiomedical optics express2024

PC12 differentiation to neuron cells activated by a low-level laser at 660 nm on UV pre-treated CR-39 scaffolds with parallel microchannels.

Somayeh Hashamdar, Parviz Parvin, Fatemeh Ramezani, Fatemeh Ahmadinouri, Amir Jafargholi, Mitra Refahizadeh, Mahzad Akbarpour, Mohammadreza Aghaei, Omid Heidari

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Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Somayeh HashamdarPhysics Department, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
Parviz ParvinPhysics Department, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
Fatemeh RamezaniPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Fatemeh AhmadinouriPhysics Department, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.ORCID https://orcid.org/0000-0001-7185-2479
Amir JafargholiLaboratory of Wave Engineering (LWE), School of Engineering, Ecole polytechnique fédérale de Lausanne (EPFL), Switzerland.
Mitra RefahizadehPhysics Department, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
Mahzad AkbarpourGMP Immune Cell Development & Manufacturing Hematopoietic Cellular Therapy Program, Department of Medicine, University of Chicago Medical Center Hospitals, Chicago, USA.
Mohammadreza AghaeiDepartment of Ocean Operations and Civil Engineering, Norwegian University of Science and Technology (NTNU), Ålesund, Norway.
Omid HeidariPhysics Department, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lack of regeneration of injured neurons in the central and peripheral neural system leads to the failure of damaged tissue repair in patients. While there is no definitive cure for most neurodegenerative diseases, new therapeutic methods that cause the proliferation and differentiation of neurons are of interest. Challenges such as the inability of neuronal cells to proliferate after injury, the lack of a stimulus for initial stimulation, and the presence of the microenvironment around CNS neurons contain several inhibitory factors that prevent neuron regeneration, thus, creating a structure similar to the extracellular matrix helps the cell proliferation in current treatment. A rapid method of neuron-like cell differentiation of PC12 cells is introduced here based on a novel synthetic scaffold. Initially, poly allyldiglycol carbonate (CR-39) substrate is textured under a high dose of ArF UV excimer laser (1000 shot, 300 mJ/pulse equivalent to 300 J/cm

Identifiers

PMID39347001
PMCPMC11427200

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.