Evidence map›Paper›PMID 39346998›Full record

ArticleBiomedical optics express2024

Measurement of retinal blood flow precision in the human eye with multimodal adaptive optics imaging.

Achyut J Raghavendra, Aashka Damani, Saige Oechsli, Laurence S Magder, Zhuolin Liu, Daniel X Hammer, Osamah J Saeedi

Abstract read
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Achyut J RaghavendraDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.ORCID https://orcid.org/0000-0002-2463-4580
Aashka DamaniDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Saige OechsliDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Laurence S MagderDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Zhuolin LiuCenter for Devices and Radiological Health (CDRH), U. S. Food and Drug Administration (FDA), Silver Spring, Maryland 20993, USA.ORCID https://orcid.org/0000-0001-8019-2054
Daniel X HammerCenter for Devices and Radiological Health (CDRH), U. S. Food and Drug Administration (FDA), Silver Spring, Maryland 20993, USA.ORCID https://orcid.org/0000-0003-0532-1914
Osamah J SaeediDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Direct Measures of Retinal Blood Flow and Autoregulation as Robust Biomarkers for Early GlaucomaR01EY031731 · NEI · UNIVERSITY OF MARYLAND BALTIMORE · PI SAEEDI, OSAMAH JAWAID · 2021 to 2025
$1.6M
NEI NIH HHS R01 EY031731NIA NIH HHS P30 AG028747
6 · The paper itself

Abstract

Impaired retinal blood flow (RBF) autoregulation plays a key role in the development and progression of several ocular diseases, including glaucoma and diabetic retinopathy. Clinically, reproducible RBF quantitation could significantly improve early diagnosis and disease management. Several non-invasive techniques have been developed but are limited for retinal microvasculature flow measurements due to their low signal-to-noise ratio and poor lateral resolution. In this study, we demonstrate reproducible vessel caliber and retinal blood flow velocity measurements in healthy human volunteers using a high-resolution (spatial and temporal) multimodal adaptive optics system with scanning laser ophthalmoscopy and optical coherence tomography.

Identifiers

PMID39346998
PMCPMC11427214

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.