Evidence map›Paper›PMID 39346899›Full record

ArticleFrontiers in cellular and infection microbiology2024

Combination of aloe emodin, emodin, and rhein from Aloe with EDTA sensitizes the resistant

Yue Zhao, Tingting Zhang, Yinping Liang, Xiaoqing Xie, Hongwei Pan, Meng Cao, Shuhua Wang, Dalei Wu, Jing Wang, Chuandong Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yue ZhaoCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Tingting ZhangState Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, China.
Yinping LiangState Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, China.
Xiaoqing XieState Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, China.
Hongwei PanDepartment of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Meng CaoResearch and Development Center, Shandong Aobo Biotechnology Co., Ltd, Liaocheng, Shandong, China.
Shuhua WangResearch and Development Center, Shandong Aobo Biotechnology Co., Ltd, Liaocheng, Shandong, China.
Dalei WuState Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, China.
Jing WangCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Chuandong WangState Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, China.
Wei HuState Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The continuous emergence and spread of polymyxin-resistant Methods: This study investigates the potential application of anthraquinone components in aloe against polymyxin-resistant Results: The findings demonstrate that aloe emodin, emodin, rhein, and their mixtures in equal mass ratios (EAR) exhibit strain-specific antibacterial activities against polymyxin-resistant Conclusions: The combination of EAR and EDTA with polymyxins offers a novel therapeutic approach for managing skin infections caused by polymyxinresistant

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAloeAnthraquinonesAnti-Bacterial AgentsDisease Models, AnimalDrug SynergismEdetic AcidEmodinMicrobial Sensitivity TestsPolymyxinsAnimalsCell LineDrug Resistance, BacterialHumansMicealoe emodinAnthraquinonesAnti-Bacterial AgentsEdetic AcidEmodinPolymyxinsrheinAcinetobacter baumanniiAloeanthraquinone componentsethylenediaminetetraacetic acidpolymyxins resistance

Identifiers

PMID39346899
PMCPMC11428196

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.