Evidence map›Paper›PMID 39346893›Full record

ArticleACS omega2024

Per- and Polyfluoroalkyl (PFAS) Disruption of Thyroid Hormone Synthesis.

Semiha Kevser Bali, Rebecca Martin, Nuno M S Almeida, Catherine Saunders, Angela K Wilson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. PFAS Alter Thyroid Histology and Cellular SignalingJournal of the Endocrine Society · 2026
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Semiha Kevser BaliDepartment of Chemistry and MSU Center for PFAS Research, Michigan State University, East Lansing, Michigan 48864, United States.ORCID https://orcid.org/0000-0002-5857-6884
Rebecca MartinDepartment of Chemistry and MSU Center for PFAS Research, Michigan State University, East Lansing, Michigan 48864, United States.
Nuno M S AlmeidaDepartment of Chemistry and MSU Center for PFAS Research, Michigan State University, East Lansing, Michigan 48864, United States.ORCID https://orcid.org/0000-0002-6091-7289
Catherine SaundersDepartment of Chemistry and MSU Center for PFAS Research, Michigan State University, East Lansing, Michigan 48864, United States.
Angela K WilsonDepartment of Chemistry and MSU Center for PFAS Research, Michigan State University, East Lansing, Michigan 48864, United States.ORCID https://orcid.org/0000-0001-9500-1628

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFAS) are a group of environmental pollutants that have been linked to a variety of health problems in humans, including the disruption of thyroid functions. Herein, for the first time, the impact of PFAS on thyroid hormone synthesis is shown. Mid- to long-chain PFAS impact thyroid hormone synthesis by changing the local hydrogen bond network as well as the required orientation of hormonogenic residues, stopping the production of thyroxine (T4). Furthermore, the toxic effects of sulfonic PFAS are more prominent than those of carboxylic PFAS, highlighting that the exposure to these specific compounds can pose greater problems for thyroid homeostasis.

Identifiers

PMID39346893
PMCPMC11425649

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.