ArticleLaryngoscope investigative otolaryngology2024
Histological characterization of rat vocal fold across different postnatal periods.
Article in Laryngoscope investigative otolaryngology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A fibril-scale visco-hyperelastic model for the mechanics of vocal-fold tissues.Frontiers in bioengineering and biotechnology · 2025Article
- Histological characterization of rat vocal fold across different postnatal periods.Laryngoscope investigative otolaryngology · 2024Article
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Authors and funding
6 authors.
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Abstract
Objective: To evaluate the vocal fold histological characteristics during different postnatal periods in rats, especially older rats. Methods: Sprague-Dawley rats aged 4 days, 4 and 12 weeks, and 12 and 24 months were used for the experiment. Five larynges were obtained for each age and cut into 5-μm consecutive sections. The expression of Ki-67 was assessed using immunohistochemistry to examine cell proliferation. Elastic van Gieson staining was used to detect the collagen and elastin concentrations. The cell type was determined using multicolor immunofluorescence. Results: Ki-67 was not expressed in the macula flava (MF) of 12-week-, 12-month-, and 24-month-old adults. Collagen fibers in the lamina propria (LP) increased with age. The elastic fiber concentrations in the LP decreased significantly at 24 months ( Conclusion: The extracellular matrix in the LP increases with age, presenting as an increase in collagen with the loss of elastin, which may be due to myofibroblast proliferation. Moreover, the cellular properties or extracellular matrix components of the mature MF in rats are comparable to those in humans.
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