Evidence map›Paper›PMID 39346547›Full record

ArticleTheranostics2024

Hypoxanthine is a metabolic biomarker for inducing GSDME-dependent pyroptosis of endothelial cells during ischemic stroke.

Jing Ye, Xinyuan Bi, Shiyu Deng, Xianghui Wang, Ze Liu, Qian Suo, Jiao Wu, Haoran Chen, Yong Wang, Kun Qian and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026
    Review
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  5. In-depth characterization of the CaScientific reports · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jing YeSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Xinyuan BiSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Shiyu DengSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Xianghui WangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Ze LiuSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Qian SuoSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Jiao WuSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Haoran ChenSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Yong WangDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200030, China.
Kun QianSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Rubing ShiSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Jing ZhaoDepartment of Neurology, Minhang Hospital, Fudan University, Shanghai, 201102, China.
Guo-Yuan YangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Jian YeSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Yaohui TangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BiomarkersBlood-Brain BarrierEndothelial CellsHypoxanthineIschemic StrokePyroptosisAgedAnimalsBrain IschemiaChromatography, LiquidDisease Models, AnimalFemaleHumansInfarction, Middle Cerebral ArteryMaleMiceBiomarkersHypoxanthineEndothelial cellsGSDMEHypoxanthineMetabolic biomarkerPyroptosis

Identifiers

PMID39346547
PMCPMC11426240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.