Evidence map›Paper›PMID 39345931›Full record

ArticleOrthopaedic journal of sports medicine2024

Predictors of Anterior Cruciate Ligament Tears in Adolescents and Young Adults.

Christine M Etzel, Ozair Meghani, Brett D Owens, Mininder S Kocher, Alison E Field

Abstract read
In one paragraph

Article in Orthopaedic journal of sports medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christine M EtzelDepartment of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.ORCID https://orcid.org/0000-0003-4302-9498
Ozair MeghaniDepartment of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.ORCID https://orcid.org/0000-0002-8295-3635
Brett D OwensDepartment of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.ORCID https://orcid.org/0000-0002-9972-0096
Mininder S KocherDivision of Sports Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-7938-7820
Alison E FieldDepartment of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA.

Funding

Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0M
Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic researchU01HL145386 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI CHAVARRO, JORGE EDUARDO, MANSON, JOANN ELISABETH · 2019 to 2025
$17.8M
Sexual Orientation and Obesity: Test of a Gendered Biopsychosocial ModelR01HD066963 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI AUSTIN, S BRYN · 2011 to 2015
$3.5M
Substance Disorders, Substance Use Treatment, and Sexual Orientation in YouthR01DA033974 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI CORLISS, HEATHER L · 2013 to 2017
$3.5M
The Development of Eating Disorders in Males and FemalesR01DK059570 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI FIELD, ALISON E · 2002 to 2006
$2.5M
Empirical eating disorder classification and validation using prospective studiesR01MH087786 · NIMH · BROWN UNIVERSITY · PI FIELD, ALISON E, MICALI, NADIA · 2010 to 2014
$2.5M
Impact of Violence on Obesity & Reproductive Axes in YouthR01HD049889 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROSALIND J · 2006 to 2010
$1.6M
Patient-oriented research in early life origins of CVDK24HL068041 · NHLBI · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2001 to 2010
$1.4M
NHLBI NIH HHS K24 HL068041NHLBI NIH HHS U01 HL145386NICHD NIH HHS R01 HD049889NICHD NIH HHS R01 HD066963NIDA NIH HHS R01 DA033974NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK059570NIMH NIH HHS R01 MH087786
6 · The paper itself

Abstract

Background: Anterior cruciate ligament (ACL) injury in youth can lead to expensive treatment, lengthy rehabilitation, and long-term impairment. Injuries to the ACL are more common in adolescents who participate in organized sports. Purpose: To examine whether there is an association between age, physical activity patterns, pubertal timing (Tanner stage), or body mass index (obesity/overweight status) and the risk of developing an ACL injury in youth. Study Design: Cohort study; Level of evidence, 2. Methods: Data from the Growing Up Today Study (GUTS), a prospective cohort study of youth throughout the United States, were used in this study. From 1996 to 2003, questionnaires were sent to GUTS participants every 12 to 18 months to assess a variety of self-reported factors; in a related 2004 questionnaire, ACL tears and other diagnoses among the participants were reported. Cox proportional hazard models were run to determine the sex-specific association of activity patterns and pubertal timing with risk of developing an ACL tear. Results: A total of 4519 boys and 5622 girls (age: 9-15 years) were included, with 2.4% and 2.0% sustaining an ACL injury, respectively. Age was found to be a significant risk factor for ACL injury in both sexes (male: hazard ratio [HR] = 1.30 [95% CI, 1.14-1.48]; female: HR = 1.23 [95% CI, 1.10-1.38]). Mean hours per week engaged in vigorous activity was also predictive of a higher risk of ACL injury (male: HR = 1.04 [95% CI, 1.01-1.08]; female: HR = 1.10 [95% CI, 1.07-1.14]). The sports that were the most predictive of injury were running, basketball, soccer, and cheerleading/gymnastics in girls and running, football, and karate/martial arts in boys. Additionally, in boys, overweight/obese status was found to be a significant predictor of ACL injury (HR = 2.61 [95% CI, 1.60-4.26]). Furthermore, among 9- to 13-year-old girls, advanced Tanner stage was a strong predictor of injury risk (HR = 2.43 [95% CI, 1.10-5.36]). Conclusion: Age, time engaged in vigorous activity, overweight/obese status, and advanced Tanner stage were associated with an increased risk of ACL injury in young adults and adolescents. Further research with follow-up data will help complement this study and continue to highlight the risk factors associated with ACL reconstruction in adolescents and young adults.

Indexed as

adolescentsanterior cruciate ligamentepidemiologyprospective cohort study

Identifiers

PMID39345931
PMCPMC11439179

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.