Evidence map›Paper›PMID 39345739›Full record

ArticleToxicological research2024

Hepatocyte-specific RIG-I loss attenuates metabolic dysfunction-associated steatotic liver disease in mice via changes in mitochondrial respiration and metabolite profiles.

Jin Kyung Seok, Gabsik Yang, Jung In Jee, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee

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Article in Toxicological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jin Kyung SeokCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662 Republic of Korea.
Gabsik YangDepartment of Pharmacology, College of Korean Medicine, Woosuk University, Jeonbuk, 55338 Republic of Korea.
Jung In JeeCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662 Republic of Korea.
Han Chang KangCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662 Republic of Korea.
Yong-Yeon ChoCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662 Republic of Korea.
Hye Suk LeeCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662 Republic of Korea.
Joo Young LeeCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662 Republic of Korea.ORCID 0000-0002-6020-3040

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pattern recognition receptor (PRR)-mediated inflammation is an important determinant of the initiation and progression of metabolic diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD). In this study, we investigated whether RIG-I is involved in hepatic metabolic reprogramming in a high-fat diet (HFD)-induced MASLD model in hepatocyte-specific RIG-I-KO (RIG-I Supplementary Information: The online version contains supplementary material available at 10.1007/s43188-024-00264-x.

Indexed as

Metabolic disorderMetabolic dysfunction-associated steatotic liver diseaseMetabolismMitochondriaPattern-recognition receptors

Identifiers

PMID39345739
PMCPMC11436585

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.