ArticlebioRxiv : the preprint server for biology2024
Neural basis of collective social behavior during environmental challenge.
Tara Raam, Qin Li, Linfan Gu, Gabrielle Elagio, Kayla Y Lim, Xingjian Zhang, Stephanie M Correa, Weizhe Hong
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Tara RaamDepartment of Biological Chemistry and Department of Neurobiology, University of California, Los Angeles, CA, USA.ORCID 0000-0003-2963-8588 Qin LiDepartment of Biological Chemistry and Department of Neurobiology, University of California, Los Angeles, CA, USA.
Linfan GuDepartment of Biological Chemistry and Department of Neurobiology, University of California, Los Angeles, CA, USA.
Gabrielle ElagioDepartment of Biological Chemistry and Department of Neurobiology, University of California, Los Angeles, CA, USA.
Kayla Y LimDepartment of Biological Chemistry and Department of Neurobiology, University of California, Los Angeles, CA, USA.
Xingjian ZhangDepartment of Biological Chemistry and Department of Neurobiology, University of California, Los Angeles, CA, USA.
Stephanie M CorreaDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Weizhe HongDepartment of Biological Chemistry and Department of Neurobiology, University of California, Los Angeles, CA, USA.ORCID 0000-0003-1523-8575 Funding
Neural Circuit Mechanisms of Allogrooming BehaviorR01MH130941 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Weizhe Hong · 2022 to 2026
$3.4MNeural circuits for social modulation of a persistent negative emotional stateRF1NS132912 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HONG, WEIZHE, ZHANG, LI I · 2023 to 2023
$3.2MFunctional Dissection of Neural Circuitry Underlying Parenting BehaviorR01NS113124 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HONG, WEIZHE · 2019 to 2023
$2.6MThe Aging Autistic Brain: Multi-modal imaging to predict accelerated memory declineR01MH132746 · NIMH · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Brittany Blair Braden · 2024 to 2026
$2.2MEstrogenic modulation of neural circuits that control temperatureR01AG066821 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CORREA, STEPHANIE · 2020 to 2024
$2.1MNeural basis of collective behavior during environmental stressK99MH133159 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAAM, TARA · 2023 to 2024
$245kNeural Circuit Dissection of Prefrontal Cortex Projections in Social Dominance BehaviorF32MH123049 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAAM, TARA · 2020 to 2022
$135kShared neural circuits of prosocial and parenting behaviors in the hypothalamusF31MH134495 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIM, KAYLA Y · 2023 to 2024
$81kNIA NIH HHS R01 AG066821NIMH NIH HHS F31 MH134495NIMH NIH HHS F32 MH123049NIMH NIH HHS K99 MH133159NIMH NIH HHS R01 MH130941NIMH NIH HHS R01 MH132746NINDS NIH HHS R01 NS113124NINDS NIH HHS RF1 NS132912
6 · The paper itselfAbstract
Humans and animals have a remarkable capacity to collectively coordinate their behavior to respond to environmental challenges. However, the underlying neurobiology remains poorly understood. Here, we found that groups of mice self-organize into huddles at cold ambient temperature during the thermal challenge assay. We found that mice make active (self-initiated) and passive (partner-initiated) decisions to enter or exit a huddle. Using microendoscopic calcium imaging, we found that active and passive decisions are encoded distinctly within the dorsomedial prefrontal cortex (dmPFC). Silencing dmPFC activity in some mice reduced their active decision-making, but also induced a compensatory increase in active decisions by non-manipulated partners, conserving the group's overall huddle time. These findings reveal how collective behavior is implemented in neurobiological mechanisms to meet homeostatic needs during environmental challenges.
Identifiers
PMID39345632
PMCPMC11429680
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