Evidence map›Paper›PMID 39345600›Full record

ArticlebioRxiv : the preprint server for biology2024

The pericardium forms as a distinct structure during heart formation.

Hannah R Moran, Obed O Nyarko, Rebecca O'Rourke, Ryenne-Christine K Ching, Frederike W Riemslagh, Brisa Peña, Alexa Burger, Carmen C Sucharov, Christian Mosimann

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Hannah R MoranDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-8056-5762
Obed O NyarkoDivision of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-9184-6965
Rebecca O'RourkeDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0003-1198-6963
Ryenne-Christine K ChingDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.ORCID 0009-0008-2846-5578
Frederike W RiemslaghDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-8530-3339
Brisa PeñaDivision of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0003-4224-6626
Alexa BurgerDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-7137-3910
Carmen C SucharovDivision of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0003-0349-1776
Christian MosimannDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-0749-2576

Funding

Predoctoral Training in the Genetics of Development, Disease and RegenerationT32GM141742 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Bruce H Appel, Jeffrey Kyle Moore · 2021 to 2026
$1.9M
Mechanisms of Cardiac Injury Resolution by CX3CR1+ MacrophagesR01HL169578 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Ronald Joseph Vagnozzi · 2023 to 2026
$1.7M
Decoding the transcriptional mechanisms of pericardium formationR01HL168097 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Christian Mosimann · 2024 to 2026
$1.7M
Injectable Carbon Nanotube-Functionalized Hydrogel for miRNA DeliveryK25HL148386 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI PENA CASTELLANOS, BRISA MARISOL · 2020 to 2024
$891k
Developmental causes of syndromic Thrombocytopenia and co-morbiditiesR01DK129350 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BURGER, ALEXA · 2022 to 2024
$690k
Investigations of Pathologic Remodeling Using Pediatric Heart Failure SerumK24HL150630 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SUCHAROV, CARMEN C · 2020 to 2024
$537k
Determining the role of tissue stiffness in the development of Alzheimer's disease pathologyR21AG080257 · NIA · UNIVERSITY OF COLORADO DENVER · PI JOHNSON, NOAH RAY, PARK, DAE WON · 2023 to 2024
$407k
Defining the developmental mechanisms of pericardium formationF31HL167580 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MORAN, HANNAH ROSE · 2023 to 2024
$65k
American Heart Association-American Stroke Association 24DIVSUP1281949NHLBI NIH HHS F31 HL167580NHLBI NIH HHS K24 HL150630NHLBI NIH HHS K25 HL148386NHLBI NIH HHS R01 HL168097NHLBI NIH HHS R01 HL169578NIA NIH HHS R21 AG080257NIDDK NIH HHS R01 DK129350NIGMS NIH HHS T32 GM141742
6 · The paper itself

Abstract

The heart integrates diverse cell lineages into a functional unit, including the pericardium, a mesothelial sac that supports heart movement, homeostasis, and immune responses. However, despite its critical roles, the developmental origins of the pericardium remain uncertain due to disparate models. Here, using live imaging, lineage tracking, and single-cell transcriptomics in zebrafish, we find the pericardium forms within the lateral plate mesoderm from dedicated anterior mesothelial progenitors and distinct from the classic heart field. Imaging of transgenic reporters in zebrafish documents lateral plate mesoderm cells that emerge lateral of the classic heart field and among a continuous mesothelial progenitor field. Single-cell transcriptomics and trajectories of

Identifiers

PMID39345600
PMCPMC11429720

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.