Evidence map›Paper›PMID 39345594›Full record

ArticlebioRxiv : the preprint server for biology2024

The Pattern and Staging of Brain Atrophy in Spinocerebellar Ataxia Type 2 (SCA2): MRI Volumetrics from ENIGMA-Ataxia.

Jason W Robertson, Isaac Adanyeguh, Benjamin Bender, Sylvia Boesch, Arturo Brunetti, Sirio Cocozza, Léo Coutinho, Andreas Deistung, Stefano Diciotti, Imis Dogan and 26 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Jason W RobertsonFaculty of Computer Science, Dalhousie University, Halifax, Canada.ORCID 0000-0003-0579-0403
Isaac AdanyeguhSorbonne Université, Institut du Cerveau, INSERM, CNRS, AP-HP, Paris, France.
Benjamin BenderDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
Sylvia BoeschDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0003-1657-7368
Arturo BrunettiDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy.ORCID 0000-0001-7057-3494
Sirio CocozzaDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy.ORCID 0000-0002-0300-5160
Léo CoutinhoPost-Graduate Program of Internal Medicine, Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil.ORCID 0000-0003-4921-2939
Andreas DeistungUniversity Clinic and Outpatient Clinic for Radiology, Department for Radiation Medicine, University Hospital Halle (Saale), University Medicine Halle, Halle (Saale), Germany.ORCID 0000-0002-2427-1302
Stefano DiciottiDepartment of Electrical, Electronic, and Information Engineering "Guglielmo Marconi", University of Bologna, Bologna, Italy.
Imis DoganDepartment of Neurology, RWTH Aachen University, Aachen, Germany.
Alexandra DurrSorbonne Université, Institut du Cerveau, INSERM, CNRS, AP-HP, Paris, France.ORCID 0000-0002-8921-7104
Juan Fernandez-RuizNeuropsychology Laboratory, Department of Physiology, Faculty of Medicine, National Autonomous University of Mexico, Mexico.ORCID 0000-0002-4038-0904
Sophia L GörickeCenter for Translational Neuro- and Behavioral Sciences (C-TNBS), Essen University Hospital, University of Duisburg-Essen, Essen, Germany.
Marina GrisoliDepartment of Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.ORCID 0000-0002-7663-446X
Shuo HanDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, USA.
Caterina MariottiUnit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta Milan, Italy.ORCID 0000-0003-2405-3564
Chiara MarziDepartment of Statistics, Computer Science, and Applications "Giuseppe Parenti", University of Florence, Florence, Italy.
Mario MascalchiDepartment of Clinical and Experimental Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Fanny MochelSorbonne Université, Institut du Cerveau, INSERM, CNRS, AP-HP, Paris, France.
Wolfgang NachbauerDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Lorenzo NanettiUnit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta Milan, Italy.ORCID 0000-0002-1952-4539
Anna NigriDepartment of Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.ORCID 0000-0002-1197-5458
Sergio E OnoClínica DAPI - Diagnóstico Avançado Por Imagem, Curitiba, Brazil.
Chiadi U OnyikeDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, USA.
Jerry L PrinceDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, USA.ORCID 0000-0002-6553-0876
Kathrin ReetzDepartment of Neurology, RWTH Aachen University, Aachen, Germany.ORCID 0000-0002-9730-9228
Sandro RomanzettiDepartment of Neurology, RWTH Aachen University, Aachen, Germany.ORCID 0000-0001-8519-1309
Francesco SaccàDepartment of Neuroscience and Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Naples, Italy.ORCID 0000-0002-1323-6317
Matthis SynofzikDepartment of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Tübingen, Germany.ORCID 0000-0002-2280-7273
Hélio A Ghizoni TeivePost-Graduate Program of Internal Medicine, Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil.ORCID 0000-0003-2305-1073
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, USA.ORCID 0000-0002-0046-4070
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, USA.
Dagmar TimmannCenter for Translational Neuro- and Behavioral Sciences (C-TNBS), Essen University Hospital, University of Duisburg-Essen, Essen, Germany.
Sarah H YingDepartment of Radiology, Johns Hopkins University, Baltimore, USA.
Ian H HardingQIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID 0000-0002-6843-9592
Carlos R Hernandez-CastilloFaculty of Computer Science, Dalhousie University, Halifax, Canada.

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
ENIGMA-COINSTAC-APOE2 Functional and structural connectome protective mechanisms for Alzheimer’s disease and mood disorders: Request for supplemental funds for NIH R01:1R01MH121246R01MH121246 · NIMH · OHIO STATE UNIVERSITY · PI CALHOUN, VINCE D, TURNER, JESS · 2019 to 2023
$5.0M
Automatic Cerebellar MRI Labeling In Health and DiseaseR01NS056307 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2006 to 2015
$3.0M
ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5M
Redefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine LearningRF1MH123163 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V., THOMPSON, PAUL M · 2021 to 2021
$1.2M
NCATS NIH HHS UL1 TR001079NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH121246NIMH NIH HHS RF1 MH123163NINDS NIH HHS R01 NS056307
6 · The paper itself

Abstract

Objective: Spinocerebellar ataxia type 2 (SCA2) is a rare, inherited neurodegenerative disease characterised by progressive deterioration in both motor coordination and cognitive function. Atrophy of the cerebellum, brainstem, and spinal cord are core features of SCA2, however the evolution and pattern of whole-brain atrophy in SCA2 remain unclear. We undertook a multi-site, structural magnetic resonance imaging (MRI) study to comprehensively characterize the neurodegeneration profile of SCA2. Methods: Voxel-based morphometry analyses of 110 participants with SCA2 and 128 controls were undertaken to assess groupwise differences in whole-brain volume. Correlations with clinical severity and genotype, and cross-sectional profiling of atrophy patterns at different disease stages, were also performed. Results: Atrophy in SCA2 relative to controls was greatest (Cohen's Interpretation: The magnitude and pattern of brain atrophy evolves over the course of SCA2, with widespread, non-uniform involvement across the brainstem, cerebellar tracts, and cerebellar cortex; and late involvement of the cerebral cortex and striatum.

Identifiers

PMID39345594
PMCPMC11429976

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.