Evidence map›Paper›PMID 39345578›Full record

ArticlebioRxiv : the preprint server for biology2024

Hippocampal γCaMKII dopaminylation promotes synaptic-to-nuclear signaling and memory formation.

Andrew F Stewart, Sasha L Fulton, Romain Durand-de Cuttoli, Robert E Thompson, Peng-Jen Chen, Elizabeth Brindley, Bulent Cetin, Lorna A Farrelly, Rita Futamura, Sarah Claypool and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Andrew F StewartNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Sasha L FultonNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Romain Durand-de CuttoliNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Robert E ThompsonDepartment of Chemistry, Princeton, New Jersey 08544, USA.
Peng-Jen ChenDepartment of Pharmacological Sciences and Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Elizabeth BrindleyNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Bulent CetinNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Lorna A FarrellyNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Rita FutamuraNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Sarah ClaypoolNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Ryan M BastleNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Giuseppina Di SalvoNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Christopher PeraltaThe Rockefeller University Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA.
Henrik MolinaThe Rockefeller University Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA.
Erdene BaljinnyamInstitute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Samuele G MarroNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Scott J RussoNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Robert J DeVitaDepartment of Pharmacological Sciences and Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Tom W MuirDepartment of Chemistry, Princeton, New Jersey 08544, USA.
Ian MazeNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Funding

ROLE OF PERIPHERAL IMMUNE-DERIVED MMP8 IN STRESS SUSCEPTIBILITYR01MH104559 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCOTT JAMES RUSSO · 2014 to 2026
$9.2M
Molecular studies of neural histone monoaminylation in normal and aberrant brain plasticityR01MH116900 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ian S. Maze · 2019 to 2026
$4.7M
Structure, Function and Applications of InteinsR01GM086868 · NIGMS · ROCKEFELLER UNIVERSITY · PI MUIR, TOM · 2008 to 2025
$4.4M
Structure-activity relationships governing mammalian SWI/SNF chromatin remodeling activity as a function of chromatin stateR01CA259365 · NCI · DANA-FARBER CANCER INST · PI Cigall Kadoch, Tom Muir · 2021 to 2026
$4.2M
Neural Circuit Mechanisms of Stress-Impaired Social RewardR01MH127820 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUSSO, SCOTT JAMES · 2021 to 2025
$3.5M
Contributions of aberrant synaptic protein monoaminylation to opiate use disorderR01DA056595 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAVID M DIETZ, Ian S. Maze · 2022 to 2026
$3.5M
Modulate Cullin-RING E3 ubiquitin ligases by small molecule agentsR01CA251425 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DEVITA, ROBERT J, PAN, ZHEN-QIANG · 2020 to 2024
$3.5M
Training Program in Substance Use DisordersT32DA053558 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Paul J. Kenny · 2021 to 2026
$2.6M
Sex Differences in Neural Circuit Mechanisms of AggressionR01MH133299 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCOTT JAMES RUSSO · 2023 to 2026
$2.6M
Identification of CaMKII as a novel substrate of dopaminylation following heroin self administrationF31DA055462 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STEWART, ANDREW F · 2022 to 2023
$91k
Characterizing effects of OFC astrocyte plasticity in inflammation response and stress vulnerability with single-cell resolutionF99NS125774 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FULTON, SASHA · 2021 to 2021
$45k
NCI NIH HHS R01 CA251425NCI NIH HHS R01 CA259365NIDA NIH HHS F31 DA055462NIDA NIH HHS R01 DA056595NIDA NIH HHS T32 DA053558NIGMS NIH HHS R01 GM086868NIMH NIH HHS R01 MH104559NIMH NIH HHS R01 MH116900NIMH NIH HHS R01 MH127820NIMH NIH HHS R01 MH133299NINDS NIH HHS F99 NS125774
6 · The paper itself

Abstract

Protein monoaminylation is a class of posttranslational modification (PTM) that contributes to transcription, physiology and behavior. While recent analyses have focused on histones as critical substrates of monoaminylation, the broader repertoire of monoaminylated proteins in brain remains unclear. Here, we report the development/implementation of a chemical probe for the bioorthogonal labeling, enrichment and proteomics-based detection of dopaminylated proteins in brain. We identified 1,557 dopaminylated proteins - many synaptic - including γCaMKII, which mediates Ca

Identifiers

PMID39345578
PMCPMC11430047

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.