Evidence map›Paper›PMID 39345551›Full record

ArticlebioRxiv : the preprint server for biology2024

Modulating DNA Polα Enhances Cell Reprogramming Across Species.

Rajesh Ranjan, Binbin Ma, Ryan J Gleason, Yijun Liao, Yingshan Bi, Brendon E M Davis, Guanghui Yang, Maggie Clark, Vikrant Mahajan, Madison Condon and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rajesh RanjanDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Binbin MaDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Ryan J GleasonDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Yijun LiaoDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Yingshan BiDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Brendon E M DavisDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Guanghui YangDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Maggie ClarkDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Vikrant MahajanDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Madison CondonDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Nichole A BroderickDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Xin ChenDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-6990-0926

Funding

CELLULAR AND MOLECULAR BIOLOGYT32GM007231 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VAN DOREN, MARK B · 1985 to 2020
$18.4M
Cellular and Molecular BiologyT32GM141804 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI John Kim · 2021 to 2026
$5.1M
Study epigenetic inheritance during development, homeostasis and regenerationR35GM127075 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Xin Chen · 2018 to 2026
$3.2M
Epigenetic Regulation of Germ Cell Differentiation from a Stem Cell LineageR01HD102474 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CHEN, XIN · 2020 to 2024
$1.7M
NICHD NIH HHS R01 HD102474NIGMS NIH HHS R35 GM127075NIGMS NIH HHS T32 GM007231NIGMS NIH HHS T32 GM141804
6 · The paper itself

Abstract

As a fundamental biological process, DNA replication ensures the accurate copying of genetic information. However, the impact of this process on cellular plasticity in multicellular organisms remains elusive. Here, we find that reducing the level or activity of a replication component, DNA Polymerase α (Polα), facilitates cell reprogramming in diverse stem cell systems across species. In

Indexed as

dedifferentiationDNA polymeraseDrosophilagermline stem cellshuman fibroblastsinduced pluripotent stem cellsintestinal stem cellsReprogramming

Identifiers

PMID39345551
PMCPMC11429986

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.