Evidence map›Paper›PMID 39345535›Full record

ArticlebioRxiv : the preprint server for biology2024

Myofiber-specific FoxP1 knockout protects against pancreatic cancer-induced muscle wasting in male but not female mice.

Martin M Schonk, Jeremy B Ducharme, Daria Neyroud, Rachel L Nosacka, Haley O Tucker, Sarah M Judge, Andrew R Judge

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Martin M SchonkDepartment of Physical Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-0035-8219
Jeremy B DucharmeDepartment of Physical Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
Daria NeyroudDepartment of Physical Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
Rachel L NosackaDepartment of Physical Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
Haley O TuckerDepartment of Molecular Biosciences and the Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA.
Sarah M JudgeDepartment of Physical Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
Andrew R JudgeDepartment of Physical Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.

Funding

University of Florida Health Cancer Center Support GrantP30CA247796 · NCI · UNIVERSITY OF FLORIDA · PI Alison Ivey · 2023 to 2026
$10.9M
FOXO signaling and skeletal muscle atrophyR01AR060209 · NIAMS · UNIVERSITY OF FLORIDA · PI JUDGE, ANDREW ROBERT · 2011 to 2021
$4.2M
MAR MEDIATED GENETIC SWITCH FOR IGH ENHANCER CONTROLR01CA031534 · NCI · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI TUCKER, HALEY O · 1985 to 2012
$2.9M
The Complement System and Cancer CachexiaR01AR081648 · NIAMS · UNIVERSITY OF FLORIDA · PI Carl Atkinson, Andrew Robert Judge · 2022 to 2026
$2.3M
Team-based Interdisciplinary Cancer Research Training ProgramT32CA257923 · NCI · UNIVERSITY OF FLORIDA · PI SIEMANN, DIETMAR W · 2021 to 2025
$1.2M
NCI NIH HHS P30 CA247796NCI NIH HHS R01 CA031534NCI NIH HHS T32 CA257923NIAMS NIH HHS R01 AR060209NIAMS NIH HHS R01 AR081648
6 · The paper itself

Abstract

Cancer cachexia affects up to 80% of cancer patients and results in reduced quality of life and survival. We previously demonstrated that the transcriptional repressor Forkhead box P1 (FoxP1) is upregulated in skeletal muscle of cachectic mice and people with cancer, and when overexpressed in skeletal muscle is sufficient to induce pathological features characteristic of cachexia. However, the role of myofiber-derived FoxP1 in both normal muscle physiology and cancer-induced muscle wasting remains largely unexplored. To address this gap, we generated a conditional mouse line with myofiber-specific ablation of FoxP1 (FoxP1

Indexed as

Biological sexCancer cachexiaForkhead box P1Muscle wastingPancreatic cancer

Identifiers

PMID39345535
PMCPMC11429864

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.