Evidence map›Paper›PMID 39345527›Full record

ArticlebioRxiv : the preprint server for biology2024

Craters on the melanoma surface facilitate tumor-immune interactions and demonstrate pathologic response to checkpoint blockade in humans.

Aya Ludin, Georgia L Stirtz, Asaf Tal, Ajit J Nirmal, Naomi Besson, Stephanie M Jones, Kathleen L Pfaff, Michael Manos, Sophia Liu, Irving Barrera and 29 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

39 authors.

Aya LudinHarvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.
Georgia L StirtzHarvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.
Asaf TalHarvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.
Ajit J NirmalDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Naomi BessonCenter for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Stephanie M JonesCenter for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Kathleen L PfaffCenter for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Michael ManosCenter for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Sophia LiuBiophysics Program, Harvard University, Boston, MA 02115, USA.
Irving BarreraBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Qiyu GongBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Cecilia Pessoa RodriguesHarvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.
Aditi SahuDermatology Service, Memorial Sloan Kettering Cancer Center; New York, NY, USA.|.
Elizabeth JerisonDepartment of Physics, University of Chicago, Chicago, IL 60637, USA, Institute for Biophysical Dynamics, and James Franck Institute.
Joao V AlessiLowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Biagio RicciutiLowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Douglas S RichardsonHarvard Center for Biological Imaging, Department of Molecular and Cellular Biology, Harvard University; Cambridge, MA, USA.
Jodi D WeissHarvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.
Hadley M MoreauHarvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.
Meredith E StanhopeHarvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.
Alexander B AfeyanHarvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.
James SeftonHarvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.
Wyatt D McCallHarvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.
Emily FormatoHarvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.
Song YangStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute; Boston, MA, USA.
Yi ZhouStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute; Boston, MA, USA.
David P Hoytema van KonijnenburgDivision of Immunology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Hannah L ColeHarvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.
Miguel CordovaDermatology Service, Memorial Sloan Kettering Cancer Center; New York, NY, USA.|.
Liang DengDermatology Service, Memorial Sloan Kettering Cancer Center; New York, NY, USA.|.
Milind RajadhyakshaDermatology Service, Memorial Sloan Kettering Cancer Center; New York, NY, USA.|.
Stephen R QuakeDepartment of Bioengineering and Applied sciences, Stanford University, Stanford, CA, USA.
Mark M AwadLowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Fei ChenHarvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.ORCID 0000-0003-2308-3649
Peter K SorgerLudwig Center at Harvard; Boston, MA, USA.ORCID 0000-0002-3364-1838
F Stephen HodiCenter for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Scott J RodigCenter for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
George F MurphyDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Leonard I ZonHarvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.

Funding

Transcriptional mechanisms and melanomaP01CA163222 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI DAVID E FISHER · 2013 to 2026
$25.3M
Super-Resolution ImagingP30NS072030 · NINDS · HARVARD MEDICAL SCHOOL · PI REGEHR, WADE G · 2011 to 2020
$5.8M
Integrative Prediction of Therapeutic Response in T-cell Lymphoma by Omic and Spatial ModelingR00CA256497 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI NIRMAL, AJIT JOHNSON · 2023 to 2025
$747k
Mechanisms of tumor microenvironmental regulation of T-cell infiltration in melanomaF31CA260802 · NCI · HARVARD MEDICAL SCHOOL · PI STIRTZ, GEORGIA · 2021 to 2023
$82k
NCI NIH HHS F31 CA260802NCI NIH HHS P01 CA163222NCI NIH HHS R00 CA256497NINDS NIH HHS P30 NS072030
6 · The paper itself

Abstract

Immunotherapy leads to cancer eradication despite the tumor's immunosuppressive environment. Here, we used extended long-term in-vivo imaging and high-resolution spatial transcriptomics of endogenous melanoma in zebrafish, and multiplex imaging of human melanoma, to identify domains that facilitate immune response during immunotherapy. We identified crater-shaped pockets at the margins of zebrafish and human melanoma, rich with beta-2 microglobulin (B2M) and antigen recognition molecules. The craters harbor the highest density of CD8

Identifiers

PMID39345527
PMCPMC11429731

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.