Evidence map›Paper›PMID 39345502›Full record

ArticlebioRxiv : the preprint server for biology2024

Therapeutic modulation of ROCK overcomes metabolic adaptation of cancer cells to OXPHOS inhibition and drives synergistic anti-tumor activity.

Nicholas Blazanin, Xiaobing Liang, Iqbal Mahmud, Eiru Kim, Sara Martinez, Lin Tan, Waikin Chan, Nazanin Esmaeili Anvar, Min Jin Ha, Md Qudratullah and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nicholas BlazaninDepartment of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center.ORCID 0009-0000-4171-1624
Xiaobing LiangDepartment of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center.
Iqbal MahmudDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.
Eiru KimDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.
Sara MartinezDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.
Lin TanDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.
Waikin ChanDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.
Nazanin Esmaeili AnvarDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.
Min Jin HaDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, USA.
Md QudratullahDepartment of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center.
Rosalba MinelliTRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, USA.
Michael PeoplesTRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, USA.
Philip LorenziDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.
Traver HartDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center.ORCID 0000-0002-1880-3341
Yonathan LissanuDepartment of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center.ORCID 0000-0003-1024-5303

Funding

Mechanisms and Vulnerabilities of SWI/SNF chromatin remodeling complex mutant lung cancerR37CA251629 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LISSANU, YONATHAN · 2020 to 2025
$3.3M
Targeting SMARCA2 as a therapeutic strategy in SMARCA4 mutant lung cancerR01CA272945 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Yonathan Lissanu · 2022 to 2026
$2.7M
NCI NIH HHS R01 CA272945NCI NIH HHS R37 CA251629
6 · The paper itself

Abstract

Genomic studies have identified frequent mutations in subunits of the SWI/SNF chromatin remodeling complex including

Indexed as

AMPKfunctional genomicsIACS-10759oxidative phosphorylationROCKSMARCA4

Identifiers

PMID39345502
PMCPMC11429714

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.