Evidence map›Paper›PMID 39345495›Full record

ArticlebioRxiv : the preprint server for biology2024

Cholesterol binding to VCAM-1 promotes vascular inflammation.

John P Kennelly, Xu Xiao, Yajing Gao, Sumin Kim, Soon-Gook Hong, Miranda Villanueva, Alessandra Ferrari, Lauri Vanharanta, Alexander Nguyen, Rohith T Nagari and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

John P KennellyDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA); Los Angeles, CA 90095, USA.ORCID 0000-0002-4399-3976
Xu XiaoDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA); Los Angeles, CA 90095, USA.
Yajing GaoDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA); Los Angeles, CA 90095, USA.ORCID 0000-0002-8836-4452
Sumin KimDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, 03080, Korea.
Soon-Gook HongMolecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
Miranda VillanuevaDepartment of Biological Chemistry, UCLA, Los Angeles, CA 90095, USA.
Alessandra FerrariDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA); Los Angeles, CA 90095, USA.
Lauri VanharantaDepartment of Anatomy and Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland.
Alexander NguyenDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA); Los Angeles, CA 90095, USA.
Rohith T NagariDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA); Los Angeles, CA 90095, USA.
Nikolas R BurtonDepartment of Biological Chemistry, UCLA, Los Angeles, CA 90095, USA.
Marcus J TolDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA); Los Angeles, CA 90095, USA.
Andrew P BeckerDepartment of Biological Chemistry, UCLA, Los Angeles, CA 90095, USA.
Min Jae LeeDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, 03080, Korea.
Elina IkonenDepartment of Anatomy and Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland.
Keriann M BackusDepartment of Biological Chemistry, UCLA, Los Angeles, CA 90095, USA.
Julia J MackMolecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0002-9239-8436
Peter TontonozDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA); Los Angeles, CA 90095, USA.ORCID 0000-0003-1259-0477

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Understanding the Influence of Lipid Homeostasis on T cell FunctionP01HL146358 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2019 to 2023
$11.7M
GASTROENTEROLOGYT32DK007180 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENSEN, DENNIS MICHAEL · 1986 to 2025
$10.0M
The Nuclear Receptor-Aster Pathway in Enterohepatic MetabolismR01DK126779 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TONTONOZ, PETER J · 2020 to 2024
$2.4M
A systems-level approach to decipher the protein interactome.DP2GM146246 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BACKUS, KERIANN MARIE · 2021 to 2024
$2.3M
Regulation of intestinal lipid metabolism by type-3 immune cytokineK99DK138289 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yajing Gao · 2025 to 2026
$181k
NHLBI NIH HHS P01 HL146358NIDDK NIH HHS K99 DK138289NIDDK NIH HHS R01 DK126779NIDDK NIH HHS T32 DK007180NIGMS NIH HHS DP2 GM146246NIGMS NIH HHS T32 GM008042
6 · The paper itself

Abstract

Hypercholesterolemia has long been implicated in endothelial cell (EC) dysfunction, but the mechanisms by which excess cholesterol causes vascular pathology are incompletely understood. Here we used a cholesterol-mimetic probe to map cholesterol-protein interactions in primary human ECs and discovered that cholesterol binds to and stabilizes the adhesion molecule VCAM-1. We show that accessible plasma membrane (PM) cholesterol in ECs is acutely responsive to inflammatory stimuli and that the nonvesicular cholesterol transporter Aster-A regulates VCAM-1 stability in activated ECs by controlling the size of this pool. Deletion of Aster-A in ECs increases VCAM-1 protein, promotes immune cell recruitment to vessels, and impairs pulmonary immune homeostasis. Conversely, depleting cholesterol from the endothelium

Identifiers

PMID39345495
PMCPMC11429921

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.