Evidence map›Paper›PMID 39345451›Full record

ArticlebioRxiv : the preprint server for biology2024

Cohesin-mediated chromatin remodeling controls the differentiation and function of conventional dendritic cells.

Nicholas M Adams, Aleksandra Galitsyna, Ioanna Tiniakou, Eduardo Esteva, Colleen M Lau, Jojo Reyes, Nezar Abdennur, Alexey Shkolikov, George S Yap, Alireza Khodadadi-Jamayran and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Co-Occurrence ofInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Nicholas M AdamsDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0001-5751-0480
Aleksandra GalitsynaInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-8969-5694
Ioanna TiniakouDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-8429-7045
Eduardo EstevaDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-7223-6632
Colleen M LauDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.
Jojo ReyesCenter for Immunity and Inflammation, Department of Medicine, New Jersey Medical School, Rutgers University, Newark NJ 07101, USA.ORCID 0009-0006-7160-8664
Nezar AbdennurDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0001-5814-0864
Alexey Shkolikovindependent researcher.ORCID 0009-0007-3797-0907
George S YapCenter for Immunity and Inflammation, Department of Medicine, New Jersey Medical School, Rutgers University, Newark NJ 07101, USA.ORCID 0000-0003-4814-8445
Alireza Khodadadi-JamayranDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-2495-7504
Leonid A MirnyInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-0785-5410
Boris ReizisDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-1140-7853

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Center for 3D Structure and Physics of the GenomeUM1HG011536 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DEKKER, JOB, MIRNY, LEONID A · 2020 to 2024
$11.8M
Molecular Control of Plasmacytoid Dendritic Cell Development and FunctionR37AI072571 · NIAID · UNIVERSITY OF CHICAGO · PI Boris Reizis · 2018 to 2026
$5.3M
Molecular Control of Plasmacytoid Dendritic Cell Development and FunctionR01AI072571 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REIZIS, BORIS · 2008 to 2017
$4.1M
Polymer models of mitotic and interphase chromosomesR01GM114190 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MIRNY, LEONID A · 2015 to 2023
$2.8M
Chromatin architecture as a regulator of dendritic cell functionR01AI164728 · NIAID · UNIVERSITY OF CHICAGO · PI Boris Reizis · 2022 to 2026
$2.7M
A novel regulator of dendritic cell differentiationR21AI154864 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REIZIS, BORIS · 2020 to 2021
$466k
NCI NIH HHS P30 CA016087NHGRI NIH HHS UM1 HG011536NIAID NIH HHS R01 AI072571NIAID NIH HHS R01 AI164728NIAID NIH HHS R21 AI154864NIAID NIH HHS R37 AI072571NIGMS NIH HHS R01 GM114190
6 · The paper itself

Abstract

The cohesin protein complex extrudes chromatin loops, stopping at CTCF-bound sites, to organize chromosomes into topologically associated domains, yet the biological implications of this process are poorly understood. We show that cohesin is required for the post-mitotic differentiation and function of antigen-presenting dendritic cells (DCs), particularly for antigen cross-presentation and IL-12 secretion by type 1 conventional DCs (cDC1s)

Identifiers

PMID39345451
PMCPMC11430140

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.