Evidence map›Paper›PMID 39345448›Full record

ArticlebioRxiv : the preprint server for biology2024

Endogenous hydrogen peroxide positively regulates secretion of a gut-derived peptide in neuroendocrine potentiation of the oxidative stress response in

Qi Jia, Drew Young, Qixin Zhang, Derek Sieburth

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Qi JiaDevelopment, Stem Cells and Regenerative Medicine PhD program, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.ORCID 0000-0002-8193-9786
Drew YoungNeuroscience Graduate Program, University of Southern California, Los Angeles, CA 90089.
Qixin ZhangNeuromedicine Graduate Program, University of Southern California, Los Angeles, CA 90089.
Derek SieburthZilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033.ORCID 0000-0002-1224-2758

Funding

Sphingolipid signaling in mitochondrial surveillanceR01NS110730 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SIEBURTH, DEREK · 2019 to 2023
$1.8M
Stress Regulation of Synaptic TransmissionR01NS071085 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SIEBURTH, DEREK · 2010 to 2014
$1.7M
NINDS NIH HHS R01 NS071085NINDS NIH HHS R01 NS110730
6 · The paper itself

Abstract

The gut-brain axis mediates bidirectional signaling between the intestine and the nervous system and is critical for organism-wide homeostasis. Here we report the identification of a peptidergic endocrine circuit in which bidirectional signaling between neurons and the intestine potentiates the activation of the antioxidant response in

Indexed as

AEX-4C. eleganshydrogen peroxidemitochondrianeuropeptideoxidative stressperoxiredoxinPKC-2PRDX-2protein kinase CSNAP25SOD-1SOD-3superoxide dismutasethioredoxinTRX-3

Identifiers

PMID39345448
PMCPMC11429608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.