Evidence map›Paper›PMID 39345382›Full record

ArticlebioRxiv : the preprint server for biology2024

A Strategic Blend of Stabilizing Polymers to Control Particle Surface Charge for Enhanced Mucus Transport and Cell Binding.

Corey A Stevens, Boris Sevarika, Brian K Wilson, Chia-Ming Wang, Gerardo Cárcamo-Oyarce, George Degen, Timothy Kassis, Claus Michael Lehr, Rebecca Carrier, Katharina Ribbeck and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Corey A StevensDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Boris SevarikaDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Brian K WilsonDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544.
Chia-Ming WangDepartment of Chemical Engineering, Northeastern University, Boston, MA 02115.
Gerardo Cárcamo-OyarceDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
George DegenDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Timothy KassisDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Claus Michael LehrHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), D-66123 Saarbrücken, Germany; Department of Pharmacy, Saarland University, D-66123 Saarbrücken, Germany.
Rebecca CarrierDepartment of Chemical Engineering, Northeastern University, Boston, MA 02115.
Katharina RibbeckDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Robert K Prud'hommeDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544.

Funding

TRAINING GRANTS IN ENVIROMENTAL TOXICOLOGYT32ES007020 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2024
$13.1M
NIEHS NIH HHS T32 ES007020
6 · The paper itself

Abstract

Mucus layers, viscoelastic gels abundant in anionic mucin glycoproteins, obstruct therapeutic delivery across all mucosal surfaces. We found that strongly positively charged nanoparticles (NPs) rapidly adsorb a mucin protein corona in mucus, impeding cell binding and uptake. To overcome this, we developed mucus-evading, cell-adhesive (MECS) NPs with variable surface charge using Flash NanoPrecipitation, by blending a neutral poly(ethylene glycol) (PEG) corona for mucus transport with a small amount, 5 wt%, of polycationic dimethylaminoethyl methacrylate (PDMAEMA) for increased cell targeting.

Identifiers

PMID39345382
PMCPMC11429750

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.