Evidence map›Paper›PMID 39345326›Full record

ArticleCentral European journal of urology2024

Long-term efficacy and safety of intravesical Bacillus Calmette-Guerin Moreau Polish substrain in the treatment of non-muscle invasive bladder cancer.

Wiktor Bursiewicz, Monika Złotkiewicz, Wojciech Krajewski, Krzysztof Tupikowski, Jan Kołodziej, Rolf Jünemann, Tobias Mudra, Stefanie Witecy, Tomasz Szydełko, Anna Kołodziej

Abstract read
In one paragraph

Article in Central European journal of urology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wiktor BursiewiczDepartment of Urology, Regional Specialist Hospital, Wroclaw, Poland.
Monika ZłotkiewiczUrology Unit, Lower Silesian Oncology Center, Wroclaw, Poland.
Wojciech KrajewskiDepartment of Minimally Invasive and Robotic Urology, University Hospital, Wroclaw, Poland.
Krzysztof TupikowskiUrology Unit, Lower Silesian Oncology Center, Wroclaw, Poland.
Jan KołodziejWroclaw Medical University, Wroclaw, Poland.
Rolf JünemannStatConsult, Magdeburg, Germany.
Tobias MudraAPOGEPHA Arzneimittel GmbH, Dresden, Germany.
Stefanie WitecyAPOGEPHA Arzneimittel GmbH, Dresden, Germany.
Tomasz Szydełko2 Department of Minimally Invasive and Robotic Urology, University Center of Excellence in Urology, Wroclaw, Poland.
Anna KołodziejDepartment of Urology and Urological Oncology, Wroclaw Medical University, Wroclaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Bacillus Calmette-Guerin (BCG) Moreau is under-represented in literature and comparisons with other BCG strains are rare. Material and methods: We conducted a retrospective data analysis in patients with intermediate or high-risk non-muscle invasive bladder cancer (NMIBC) to assess effectiveness and safety of BCG Moreau Polish substrain to BCG RIVM. The primary objective was to describe the real-world effectiveness of BCG Moreau in the treatment of patients with NMIBC in terms of recurrence free survival (RFS) 2 years post-treatment initiation compared to BCG RIVM. Results: The database to be analysed comprised of 967 patients with NMIBC. The primary endpoint was met since BCG Moreau was non-inferior to BCG RIVM in terms of RFS [HR: 0.920 (95%CI: 0.725; 1.168)]. There was no statistically significant difference in all secondary endpoints including time to recurrence, progression-free survival, time to progression, and overall survival. The safety profile of BCG Moreau Polish substrain was consistent with side effects and frequency of complications observed with BCG RIVM and study reports in the literature. Conclusions: BCG Moreau was effective and safe in the treatment of patients with intermediate- or high-risk non-muscle invasive bladder cancer. There was no statistically significant difference in treatment outcome between BCG Moreau and BCG RIVM strains based on real-world data.

Indexed as

Bacillus Calmette Guerinnon-muscle invasive bladder cancerreal-world datarecurrence

Identifiers

PMID39345326
PMCPMC11428373

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.