Evidence map›Paper›PMID 39345253›Full record

ArticleJournal of nutritional science2024

Prenatal vitamin C and fish oil supplement use are associated with human milk microbiota composition in the Canadian CHILD Cohort Study.

Rana F Chehab, Kelsey Fehr, Shirin Moossavi, Padmaja Subbarao, Theo J Moraes, Piushkumar Mandhane, Russell J de Souza, Stuart E Turvey, Ehsan Khafipour, Meghan B Azad and 1 more

Abstract read
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In one paragraph

Article in Journal of nutritional science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rana F ChehabDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-3558-9006
Kelsey FehrDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Shirin MoossaviDepartment of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada.
Padmaja SubbaraoHospital for Sick Children, Department of Pediatrics & Physiology and Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Theo J MoraesDepartment of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Piushkumar MandhaneDepartment of Paediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Russell J de SouzaDepartment of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Stuart E TurveyDepartment of Pediatrics, British Columbia Children's Hospital and The University of British Columbia, Vancouver, BC, Canada.
Ehsan KhafipourDepartment of Animal Science, University of Manitoba, Winnipeg, MB, Canada.
Meghan B AzadDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Michele R FormanDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal diet may modulate human milk microbiota, but the effects of nutritional supplements are unknown. We examined the associations of prenatal diet and supplement use with milk microbiota composition. Mothers reported prenatal diet intake and supplement use using self-administered food frequency and standardised questionnaires, respectively. The milk microbiota was profiled using 16S rRNA gene sequencing. Associations of prenatal diet quality, dietary patterns, and supplement use with milk microbiota diversity and taxonomic structure were examined using Wilcoxon signed-rank tests and multivariable models adjusting for relevant confounders. A subset of 645 mothers participating in the CHILD Cohort Study (originally known as the Canadian Healthy Infant Longitudinal Development Study) provided one milk sample between 2 and 6 months postpartum and used prenatal multivitamin supplements ≥4 times a week. After adjusting for confounders, vitamin C supplement use was positively associated with milk bacterial Shannon diversity (

Indexed as

Ascorbic AcidDietary SupplementsFish OilsMicrobiotaMilk, HumanAdultCanadaCohort StudiesDietFemaleHumansInfantLongitudinal StudiesMaleMaternal Nutritional Physiological PhenomenaPregnancyAscorbic AcidFish OilsRNA, Ribosomal, 16SBreastmilkCHILD Cohort StudyDietMicrobiomePregnancySupplements

Identifiers

PMID39345253
PMCPMC11428054

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.