Trial reportNeurorehabilitation and neural repair2025
IpsiHand Brain-Computer Interface Therapy Induces Broad Upper Extremity Motor Rehabilitation in Chronic Stroke.
Trial report in Neurorehabilitation and neural repair, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Neural Mechanisms of a Contralesionally-Driven Brain-Computer Interface for Motor Rehabilitation of Chronic Stroke
Ipsihand Device Use in Stroke Patients to Assess Motor Recovery of the Upper Extremity and Functional Outcomes
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A bibliometric analysis of electroencephalogram research in stroke: current trends and future directions.Frontiers in neurology · 2025Pooled it
- Multisensory BCI promotes motor recovery via high-order network-mediated interhemispheric integration in chronic stroke.BMC medicine · 2025Trial
- At-Home BCI Rehabilitation Therapy for Chronic Upper Extremity Deficit After Stroke (BCI-REHAB): A Randomized Trial.Stroke (Hoboken, N.J.) · 2026Article
- Advancing Stroke Recovery Through Operant Conditioning of Corticomuscular Coherence.Restorative neurology and neuroscience · 2026Review
- Paving the way for precision treatment of psychiatric symptoms with functional connectivity neurofeedback.Translational psychiatry · 2026Article
- EEG-based predictors of motor recovery during immersive VR-BCI rehabilitation.Scientific reports · 2026Article
- A retrospective analysis of post-stroke rehabilitation with real world use of brain-computer interface.Journal of neuroengineering and rehabilitation · 2026Article
- Brain-computer interface: an update for the clinicians.Frontiers in human neuroscience · 2026Review
- Closed-loop brain-computer interfaces for post-stroke sensorimotor loop restoration.Frontiers in neuroscience · 2026Review
- Current status and future prospects of brain-computer interfaces in the field of neurological disease rehabilitation.Frontiers in rehabilitation sciences · 2026Review
- A novel theta-controlled vibrotactile brain-computer interface to treat chronic pain: a pilot study.Scientific reports · 2024Article
- Relationship between resting-state functional connectivity and change in motor function after motor imagery intervention in patients with stroke: a scoping review.Journal of neuroengineering and rehabilitation · 2023Article
Corrections and comments
- Update of
Authors and funding
5 authors.
Funding
Abstract
backgroundChronic hemiparetic stroke patients have very limited benefits from current therapies. Brain-computer interface (BCI) engaging the unaffected hemisphere has emerged as a promising novel therapeutic approach for chronic stroke rehabilitation.
objectivesThis study investigated the effectiveness of contralesionally-controlled BCI therapy in chronic stroke patients with impaired upper extremity motor function. We further explored neurophysiological features of motor recovery driven by BCI. We hypothesized that BCI therapy would induce a broad motor recovery in the upper extremity, and there would be corresponding changes in baseline theta and gamma oscillations, which have been shown to be associated with motor recovery.
methodsTwenty-six prospectively enrolled chronic hemiparetic stroke patients performed a therapeutic BCI task for 12 weeks. Motor function assessment data and resting state electroencephalogram signals were acquired before initiating BCI therapy and across BCI therapy sessions. The Upper Extremity Fugl-Meyer assessment served as a primary motor outcome assessment tool. Theta-gamma cross-frequency coupling (CFC) was computed and correlated with motor recovery.
resultsChronic stroke patients achieved significant motor improvement in both proximal and distal upper extremity with BCI therapy. Motor function improvement was independent of Botox application. Theta-gamma CFC enhanced bilaterally over the C3/C4 motor electrodes and positively correlated with motor recovery across BCI therapy sessions.
conclusionsBCI therapy resulted in significant motor function improvement across the proximal and distal upper extremities of patients, which significantly correlated with theta-gamma CFC increases in the motor regions. This may represent rhythm-specific cortical oscillatory mechanism for BCI-driven rehabilitation in chronic stroke patients.
trial registrationAdvarra Study: https://classic.clinicaltrials.gov/ct2/show/NCT04338971 and Washington University Study: https://classic.clinicaltrials.gov/ct2/show/NCT03611855.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.