ReviewPeriodontology 20002025
Autologous platelet concentrates as adjuvant in the surgical management of medication-related osteonecrosis of the jaw.
Review in Periodontology 2000, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Comparison between different intermaxillary fixation systems in the surgical and orthopedic treatment of non-condylar mandibular fractures. Systematic review.Medicina oral, patologia oral y cirugia bucal · 2025Pooled it
- Pooled it
- Does platelet-rich fibrin enhance the outcomes of peri-implant soft tissues? A systematic review.BMC oral health · 2025Pooled it
- Efficacy of concentrated growth factor combined with coronally advanced flap in the treatment of gingival recession: a systematic review and meta-analysis.BMC oral health · 2025Pooled it
- Evaluation of the usefulness of platelet-rich fibrin (PRF) in mandibular third molar surgery with 3D facial swelling analysis: a split-mouth randomized clinical trial.Head & face medicine · 2025Trial
- Evaluating the effectiveness of advanced platelet-rich fibrin, photobiomodulation, pentoxifylline, and Alveogyl in the treatment of alveolar osteitis: a randomized controlled clinical trial.BMC oral health · 2024Trial
- Review
- Evaluation of Local and Systemic Melatonin Administration on Bone Healing After Tooth Extraction in Bisphosphonate-Treated Rats.BMC oral health · 2026Article
- Preclinical Evaluation of the Effect of Liquid Platelet-Rich Fibrin and a Volume-Stable Collagen Matrix on Periodontal Regeneration.Journal of clinical periodontology · 2026Article
- Antibiotic Prophylaxis and Postoperative Therapy in Tooth Extractions for Patients at Risk of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Scoping Review.Antibiotics (Basel, Switzerland) · 2025Review
- Evaluation of bone changes in medication-related osteonecrosis of the jaw by using fractal analysis on CBCT and panoramic radiographs.BMC oral health · 2025Article
- Efficacy of leukocyte- and platelet-rich fibrin in the treatment and prevention of medication-related osteonecrosis of the jaw: a prospective study.Medicina oral, patologia oral y cirugia bucal · 2025Article
- Use of liquid platelet-rich fibrin (liquid PRF) in temporomandibular joint disorders: A narrative review with clinical recommendations.Periodontology 2000 · 2025Review
- Effects of injectable platelet-rich fibrin (i-PRF) application as root surface biomodification on gingival fibroblasts: an in vitro study.BMC oral health · 2025Article
- Phosphate in Physiological and Pathological Mineralization: Important yet Often Unheeded.MedComm · 2025Review
- Applications of Platelet-Rich Fibrin (PRF) Membranes Alone or in Combination with Biomimetic Materials in Oral Regeneration: A Narrative Review.Biomimetics (Basel, Switzerland) · 2025Review
- Histomorphometric and immunohistochemical assessment of treated dentin matrix delivered by platelet-rich fibrin for socket preservation in rabbit model.BMC oral health · 2025Article
- Autologous platelet concentrates as adjuvant in the surgical management of medication-related osteonecrosis of the jaw.Periodontology 2000 · 2025Review
- Introduction and overview on Autogenous Platelet Concentrates.Periodontology 2000 · 2025Article
- Instructions for the use of L-PRF in different clinical indications.Periodontology 2000 · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medication-related osteonecrosis of the jaw (MRONJ) is an infectious side effect associated with bisphosphonates and monoclonal antibodies (denosumab, immune modulators, and antiangiogenic medications). Adjunctive therapies for the surgical management of MRONJ include autologous platelet concentrates (APCs). These APCs serve as a source of various cells and growth factors that aid tissue healing and regeneration. This review evaluated the use of platelet-rich plasma (PRP), plasma-rich in growth factors (PRGF), and leukocyte- and platelet-rich fibrin (L-PRF) as adjuvant therapies for the surgical management of MRONJ by conducting analyses on the results of 58 articles. Compared to surgical treatment alone, the application of PRP and L-PRF after surgery appears to increase healing in the management of patients with MRONJ. No studies have reported unhealed lesions as a result of surgical treatment of MRONJ with PRGF application or compared it with surgical treatment alone. The overall results of this review have shown favorable healing rates of MRONJ lesions managed with the application of APCs after surgical treatment; however, significant methodological limitations may limit the scientific evidence supporting their use. Further randomized controlled trials with strict criteria are needed to establish the extent to which APCs can improve wound healing and quality of life in patients with MRONJ requiring surgical treatment.
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