Evidence map›Paper›PMID 39344771›Full record

ArticleDevelopment (Cambridge, England)2024

Allometry in limb regeneration and scale-invariant patterning as the basis of normal morphogenesis from different sizes of blastemas.

Saya Furukawa, Sakiya Yamamoto, Ayaka Ohashi, Yoshihiro Morishita, Akira Satoh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Static morphogen scaling enables proportional growth in a tissue growth model inspired by axolotl limb regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Saya FurukawaGraduate School of Environmental, Life, Nature Science and Technology, Okayama University, Okayama 700-8530, Japan.
Sakiya YamamotoGraduate School of Environmental, Life, Nature Science and Technology, Okayama University, Okayama 700-8530, Japan.
Ayaka OhashiGraduate School of Environmental, Life, Nature Science and Technology, Okayama University, Okayama 700-8530, Japan.
Yoshihiro MorishitaLaboratory for Developmental Morphogeometry, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.ORCID 0000-0002-1095-5949
Akira SatohGraduate School of Environmental, Life, Nature Science and Technology, Okayama University, Okayama 700-8530, Japan.ORCID 0000-0001-9821-4290

Funding

Japan Society for the Promotion of Science 20H03264Japan Society for the Promotion of Science 20H03264, 24K02034, and 23KJ1611Okayama University
6 · The paper itself

Abstract

Axolotl (Ambystoma mexicanum) limb regeneration begins with blastemas of various sizes, in contrast to the limb developmental process. Despite this size variation, normal limb morphology, consistent with a limb stump size, is regenerated. This outcome suggests the existence of underlying scale-invariant mechanisms. To identify such mechanisms, we examined the allometric relationships between blastema size, and Sonic Hedgehog (Shh) and Fibroblast Growth Factor 8 (Fgf8) expression patterns against limb stump size. We found that all factors showed allometric rather than isometric scaling; specifically, their relative sizes decrease with an increase in limb stump size. However, the ratio of Shh/Fgf8 signaling dominant region was nearly constant, independent of blastema/body size. Furthermore, the relative spatial patterns of cell density and proliferation activity, and the relative position of first digit formation were scale invariant in the summed Shh/Fgf8 crosstalk region. This scale-invariant nature may underlie the morphogenesis of normal limbs from different sizes of blastemas.

Indexed as

Ambystoma mexicanumBody PatterningExtremitiesFibroblast Growth Factor 8Hedgehog ProteinsMorphogenesisRegenerationAnimalsCell ProliferationSignal TransductionFibroblast Growth Factor 8Hedgehog ProteinsAllometric scalingAxolotlBlastemaFgf8Limb regenerationShh

Identifiers

PMID39344771
PMCPMC11574362

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.