Evidence map›Paper›PMID 39344700›Full record

ArticleClinical transplantation and research2024

Hepatocellular carcinoma associated with progressive intrahepatic familial cholestasis type 2: a case report.

João Miguel Pimentel, Susana Nobre, Rui Caetano Oliveira, Ricardo Martins, Maria Augusta Cipriano

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical transplantation and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

João Miguel PimentelFaculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal.ORCID https://orcid.org/0000-0002-0001-191X
Susana NobreUnidade de Hepatologia e Transplantação Hepática Pediátrica, Unidade Local de Saúde de Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0001-6749-8681
Rui Caetano OliveiraFaculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal.ORCID https://orcid.org/0000-0002-7202-8059
Ricardo MartinsFaculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal.ORCID https://orcid.org/0000-0001-5340-7582
Maria Augusta CiprianoDepartment of Pathology, Unidade Local de Saúde de Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0003-3736-0141

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progressive familial intrahepatic cholestasis type 2 (PFIC2) is an autosomal recessive disorder typically presenting in infancy with cholestasis and rapidly progressing to cirrhosis. PFIC has been associated with an elevated risk of hepatocellular carcinoma (HCC), a neoplasm that is uncommon in children. PFIC type 4 has the strongest link to this type of cancer, although a few cases have also been connected to PFIC2. Herein, we report the case of a 2-year-old boy who underwent liver transplantation due to PFIC2. Histological examination showed cirrhosis and four small HCCs. Over a 20-year period following the transplantation, there was no recurrence of the disease or HCC. Although rare, HCC development can occur in PFIC and may complicate the prognosis. Liver transplantation offers a potential cure for both the metabolic disease and the neoplasm.

Indexed as

Case reportCirrhosisHepatocellular carcinomaLiver transplantationProgressive familial intrahepatic cholestasis

Identifiers

PMID39344700
PMCPMC11464154

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.