Evidence map›Paper›PMID 39344638›Full record

ArticleJournal of the American Heart Association2024

Antiphospholipid Antibodies Modify the Prognostic Value of Baseline Platelet Count for Clinical Outcomes After Ischemic Stroke.

Yinan Wang, Pinni Yang, Zhengbao Zhu, Hao Peng, Xiaoqing Bu, Qingyun Xu, Aili Wang, Jing Chen, Tan Xu, Yonghong Zhang and 1 more

Abstract read
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In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yinan WangDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases Suzhou Medical College of Soochow University Suzhou China.ORCID 0000-0003-2967-6058
Pinni YangDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases Suzhou Medical College of Soochow University Suzhou China.ORCID 0000-0001-7327-3294
Zhengbao ZhuDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases Suzhou Medical College of Soochow University Suzhou China.ORCID 0000-0001-5500-0014
Hao PengDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases Suzhou Medical College of Soochow University Suzhou China.ORCID 0000-0001-6277-662X
Xiaoqing BuDepartment of Epidemiology, School of Public Health Chongqing Medical University Chongqing China.ORCID 0009-0007-4581-0444
Qingyun XuDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases Suzhou Medical College of Soochow University Suzhou China.
Aili WangDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases Suzhou Medical College of Soochow University Suzhou China.
Jing ChenDepartment of Epidemiology Tulane University School of Public Health and Tropical Medicine New Orleans LA USA.ORCID 0000-0002-9035-9126
Tan XuDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases Suzhou Medical College of Soochow University Suzhou China.
Yonghong ZhangDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases Suzhou Medical College of Soochow University Suzhou China.ORCID 0000-0001-6188-3490
Jiang HeDepartment of Epidemiology Tulane University School of Public Health and Tropical Medicine New Orleans LA USA.ORCID 0000-0002-8286-9652

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntiphospholipid antibodies (aPLs) have been reported to be involved in platelet-mediated thrombosis and inflammation, but the impact on the prognosis of ischemic stroke remains unclear. We aimed to examine whether the association between baseline platelet count (PLT) and long-term clinical outcomes within 2 years after ischemic stroke onset is modulated by aPLs. METHODS AND

resultsA total of 2938 patients with ischemic stroke were included in this prospective cohort study. Cox proportional hazards regression models were used to assess the association between the baseline PLT stratified by aPLs status and 2-year clinical outcomes after stroke onset, and an interaction effect between PLT and aPLs on clinical outcomes was tested by likelihood ratio test. There was a significant interaction effect of aPLs and PLT on recurrent stroke (

conclusionsThe aPLs had a modifying effect on the association between PLT and clinical outcomes within 2 years after ischemic stroke onset. Increased PLT was associated with recurrent stroke and cardiovascular events after ischemic stroke onset among patients with aPL positive, but not in those with aPL negative.

Indexed as

Antibodies, AntiphospholipidIschemic StrokeRecurrenceAgedBiomarkersBlood PlateletsFemaleHumansMaleMiddle AgedPlatelet CountPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsAntibodies, AntiphospholipidBiomarkersantiphospholipid antibodiesischemic strokeplatelet countprognosis

Identifiers

PMID39344638
PMCPMC11681479

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.