Evidence map›Paper›PMID 39344634›Full record

ArticleRNA biology2024

Both host and parasite non-coding RNAs co-ordinate the regulation of macrophage gene expression to reduce pro-inflammatory immune responses and promote tissue repair pathways during infection with

Dayna Sais, Sumaiya Chowdhury, John P Dalton, Nham Tran, Sheila Donnelly

Abstract read
In one paragraph

Article in RNA biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Current research in parasitology & vector-borne diseases · 2025
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dayna SaisSchool of Biomedical Engineering, Faculty of Engineering and Information Technology, The University of Technology Sydney, Ultimo, NSW, Australia.
Sumaiya ChowdhurySchool of Biomedical Engineering, Faculty of Engineering and Information Technology, The University of Technology Sydney, Ultimo, NSW, Australia.
John P DaltonMolecular Parasitology Laboratory, School of Natural Sciences, University of Galway, Galway, Ireland.
Nham TranSchool of Biomedical Engineering, Faculty of Engineering and Information Technology, The University of Technology Sydney, Ultimo, NSW, Australia.ORCID 0000-0001-7747-2530
Sheila DonnellySchool of Life Sciences, Faculty of Science, The University of Technology Sydney, Ultimo, NSW, Australia.ORCID 0000-0003-2005-3698

Funding

Australian Research Council Discovery Project DP210101337Science Foundation Ireland (SFI) Professorship 17/RP/5368
6 · The paper itself

Abstract

Parasitic worms (helminths) establish chronic infection within mammalian hosts by strategically regulating their host's immune responses. Deciphering the mechanisms by which host non-coding RNAs (ncRNA) co-ordinate the activation and regulation of immune cells is essential to understanding host immunity and immune-related pathology. It is also important to comprehend how pathogens secrete specific ncRNAs to manipulate gene expression of host immune cells and influence their response to infection. To investigate the contribution of both host and helminth derived ncRNAs to the activation and/or regulation of innate immune responses during a parasite infection, we examined ncRNA expression in the peritoneal macrophages from mice infected with

Indexed as

Fasciola hepaticaFascioliasisGene Expression RegulationHost-Parasite InteractionsMicroRNAsAnimalsFemaleImmunity, InnateMacrophagesMacrophages, PeritonealMiceRNA, UntranslatedMicroRNAsRNA, UntranslatedFasciola hepaticahelminthhost-parasite interactionsimmune-regulationlncRNAmacrophagesmiRNAnon-coding miRNAspro-inflammatory response

Identifiers

PMID39344634
PMCPMC11445894

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.