Evidence map›Paper›PMID 39343903›Full record

ArticleMicrobial cell factories2024

The influence of growth rate-controlling feeding strategy on the surfactin production in Bacillus subtilis bioreactor processes.

Eric Hiller, Manuel Off, Alexander Hermann, Maliheh Vahidinasab, Elvio Henrique Benatto Perino, Lars Lilge, Rudolf Hausmann

Abstract read
In one paragraph

Article in Microbial cell factories, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Biotechnological Potential of RhizosphericInternational journal of molecular sciences · 2026
    Article
  3. Microorganisms · 2026
    Article
  4. Article
  5. Enhanced vitamin BSynthetic and systems biotechnology · 2026
    Article
  6. Two EngineeredBiology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Antimicrobial Activity ofInternational journal of molecular sciences · 2025
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eric HillerDepartment of Bioprocess Engineering, Institute of Food Science and Biotechnology, University of Hohenheim, Stuttgart, Germany.ORCID http://orcid.org/0009-0000-3815-920X
Manuel OffDepartment of Bioprocess Engineering, Institute of Food Science and Biotechnology, University of Hohenheim, Stuttgart, Germany.ORCID http://orcid.org/0009-0009-3585-6822
Alexander HermannDepartment of Bioprocess Engineering, Institute of Food Science and Biotechnology, University of Hohenheim, Stuttgart, Germany.ORCID http://orcid.org/0009-0000-5431-0723
Maliheh VahidinasabDepartment of Bioprocess Engineering, Institute of Food Science and Biotechnology, University of Hohenheim, Stuttgart, Germany.ORCID http://orcid.org/0000-0002-0660-787X
Elvio Henrique Benatto PerinoDepartment of Bioprocess Engineering, Institute of Food Science and Biotechnology, University of Hohenheim, Stuttgart, Germany. eperino@uni-hohenheim.de.ORCID http://orcid.org/0000-0003-0372-260X
Lars LilgeDepartment of Bioprocess Engineering, Institute of Food Science and Biotechnology, University of Hohenheim, Stuttgart, Germany. lars.lilge@uni-hohenheim.de.ORCID http://orcid.org/0000-0002-7693-477X
Rudolf HausmannDepartment of Bioprocess Engineering, Institute of Food Science and Biotechnology, University of Hohenheim, Stuttgart, Germany.ORCID http://orcid.org/0000-0002-2327-7120

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe production of surfactin, an extracellular accumulating lipopeptide produced by various Bacillus species, is a well-known representative of microbial biosurfactant. However, only limited information is available on the correlation between the growth rate of the production strain, such as B. subtilis BMV9, and surfactin production. To understand the correlation between biomass formation over time and surfactin production, the availability of glucose as carbon source was considered as main point. In fed-batch bioreactor processes, the B. subtilis BMV9 was used, a strain well-suited for high cell density fermentation. By adjusting the exponential feeding rates, the growth rate of the surfactin-producing strain, was controlled.

resultsUsing different growth rates in the range of 0.075 and 0.4 h

conclusionsOverall, the parameter of adjusting exponential feeding rates have an important impact on the B. subtilis productivity in terms of surfactin production in fed-batch bioreactor processes. A growth rate of 0.25 h

Indexed as

Bacillus subtilisBiomassBioreactorsFermentationGlucoseLipopeptidesBatch Cell Culture TechniquesPeptides, CyclicSurface-Active AgentsGlucoseLipopeptidesPeptides, CyclicSurface-Active Agentssurfactin peptideBacillus subtilisBioprocess engineeringBioreactorFed-batchSurfactin

Identifiers

PMID39343903
PMCPMC11440882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.