Evidence map›Paper›PMID 39343867›Full record

ArticleJournal of bioenergetics and biomembranes2024

PRKN-mediated the ubiquitination of IQGAP3 regulates cell growth, metastasis and ferroptosis in early-onset colorectal cancer.

Gun Chen, Linghua Cong, Chijiang Gu, Ping Li

Abstract read
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In one paragraph

Article in Journal of bioenergetics and biomembranes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gun ChenDepartment of Pathology, The Affiliated People's Hospital of Ningbo University, No. 251, Baizhang Street, Yinzhou District, Ningbo, 315000, China. nbchengun@163.com.
Linghua CongDepartment of Pathology, The Affiliated People's Hospital of Ningbo University, No. 251, Baizhang Street, Yinzhou District, Ningbo, 315000, China.
Chijiang GuDepartment of Gastrointestinal Surgery, The Affiliated People's Hospital of Ningbo University, Ningbo, 315000, China.
Ping LiDepartment of Pathology, The Affiliated People's Hospital of Ningbo University, No. 251, Baizhang Street, Yinzhou District, Ningbo, 315000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High IQ motif-containing GTPase activating protein 3 (IQGAP3) expression is considered to be associated with poor prognosis of colorectal cancer (CRC). However, its role in early-onset CRC (EOCRC) progress is unclear. The mRNA and protein levels of IQGAP3 and Parkin (PRKN) were examined by qRT-PCR and western blot. Cell proliferation, apoptosis and metastasis were determined by CCK8 assay, EdU assay, flow cytometry and transwell assay. ROS, MDA, GSH, Fe

Indexed as

Cell ProliferationColorectal NeoplasmsFerroptosisNeoplasm MetastasisUbiquitinationAnimalsCell Line, TumorFemaleGTPase-Activating ProteinsHumansMaleMiceMice, NudeUbiquitin-Protein LigasesGTPase-Activating ProteinsIQGAP3 protein, humanUbiquitin-Protein LigasesEarly-onset CRCFerroptosisIQGAP3PRKNUbiquitination

Identifiers

PMID39343867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.